深圳市1994～2001年检出脊髓灰质炎疫苗株病毒的急性弛缓性麻痹病例流行病学分析  

Epidemiological Analysis of the AFP Cases with Isolation of Polio Vaccine Virus Strains in Shenzhen in 1994～2001

作　　者：单芙香[1] 吴坤森[1] 袁芝琴[1] 苏小宏[1] 蔡创辉[1] 谭洁[1] 

机构地区：[1]深圳市疾病预防控制中心,广东深圳518020

出　　处：《中国计划免疫》2002年第6期320-322,共3页Chinese Journal of Vaccines and Immunization

摘　　要：为了解深圳市检出脊髓灰质炎 (脊灰 )疫苗株病毒的急性弛缓性麻痹 (AFP)病例流行病学特征及疫苗相关麻痹型脊灰 (VAPP)病例发生情况 ,对 1 994～ 2 0 0 1年检出脊灰疫苗株病毒的AFP病例进行分析。结果显示 :病例分布在 0～ 3岁儿童 ,男性多于女性 ;发病时间、地区无明显聚集趋势 ;无脊灰疫苗免疫史的占 55 .55 % ,均为外来流动儿童 ;检出脊灰疫苗株Ⅱ型病毒占 44 .45 % ,残留麻痹率高。VAPP发生率为 0 .90 / 1 0 0万 ,服苗者VAPP发生率为0 .68/ 1 0 0万 ,首次服苗VAPP发生率为 4 .0 9/ 1 0 0万 ,服苗接触者VAPP发生率为 0 .2 3/ 1 0 0万。This study was to make clear the epidemiological character of AFP cases with isdation of polio vaccine virus strains and the occurrence of vaccine associated paralytic poliomyelitis(VAPP) in 1994～2001 in Shenzhen.The results showed that all the AFP cases occurred in 0～3 year old children,the male was more than the female.No obvious gathering phenomenon of disease onset and geographical distribution of the cases were seen.55.55% of the cases were the nonvaccinated floating children.44.45% of the vaccine strains isolated from AFP cases were type Ⅱ polio virus and most of the cases were of residue paralysis.Estimation of the general incidence of VAPP was 0.90/1,000,000,of which the cases vaccinated was 0.68/1,000,000,the nonvaccinated contact was 0.23/1,000,000.The incidence of the newborns after their first time OPV immunization was 4.09/1,000,000.The study suggested that polio Ⅱ vaccine virus strain had once circulated in Shenzhen.It reminds us that to enhane the extra environmental surveillance for polio virus is necessary.

关 键 词：深圳市 1994-2001年 脊髓灰质炎疫苗株病毒 急性弛缓性麻痹 疫苗相关麻痹型脊髓灰质炎 AFP 流行病学 

分 类 号：R512.4[医药卫生—内科学]