耳草属植物的化学研究I.黄毛耳草中环烯醚萜甙的分离和鉴定  

CHEMICAL INVESTIGATION OF GENUS HEDYOTIS II. ISOLATION AND IDENTIFICATION OF IRIDOIDS FROM HEDYOTIS CHRYSOTRICHA

作　　者：彭江南[1,2,3] 冯孝章[1,2,3] 李光玉 梁晓天[1,2,3] 

机构地区：[1]中国医学科学院 [2]中国协和医科大学药物研究所 [3]军事医学科学院仪器中心

出　　处：《药学学报》1997年第12期908-913,共6页Acta Pharmaceutica Sinica

摘　　要：从中药黄毛耳草（Ｈｅｄｙｏｔｉｓｃｈｒｙｓｏｔｒｉｃｈａ）中分离鉴定出１０个环烯醚萜类化合物，其中８个已知物为：车叶草甙（ａｓｐｅｒｕｌｏｓｉｄｅ，１），鸡屎藤甙甲酯（ｓｃａｎｄｏｓｉｄｅｍｅｔｈｙｌｅｓｔｅｒ，２），车叶草酸（ａｓｐｅｒｕｌｏｓｉｄｉｃａｃｉｄ，３），去乙酰车叶草酸（ｄｅａｃｅｔｙｌａｓｐｅｒｕｌｏｓｉｄｉｃａｃｉｄ，４），马钱子素（ｌｏｇａｎｉｎ，５），去乙酰车叶草甙（ｄｅａｃｅｔｙｌａｓｐｅｒｕｌｏｓｉｄｅ，６），乙酰鸡屎藤甙甲酯（ａｃｅｔｙｌｓｃａｎｄｏｓｉｄｅｍｅｔｈｙｌｅｓｔｅｒ，７），６β羟基京尼平（６βｈｙｄｒｏｘｙｇｅｎｉｐｉｎ，８）；２个新化合物命名为耳草甙（ｈｅｄｙｏｓｉｄｅ，９），６′乙酰车叶草甙（６′ａｃｅｔｙｌａｓｐｅｒｕｌｏｓｉｄｅ，１０）。除车叶草甙外均为首次从该植物得到。Many species of genus Hedyotis (Rubiaceae) were used as folk medicine for treatment of cold, inflammation, cancer and etc. in China. The alcoholic extract of the whole plant of H.chrysotricha showed good hepatoprotective effects. From the alcocholic extract ten iridoids were isolated and their structures were elucidated as: asperuloside (1), scandoside methyl ester (2), asperulosidic acid (3), deacetyl asperulosidic acid (4), loganin (5), deacetyl asperuloside (6), acetyl scandoside methyl ester (7), 6βhydroxygenipin (8) and two new compounds named hedyoside (9) and 6′acetylasperuloside (10), by means of chemical and spectral methods.

关 键 词：黄毛耳草 环烯醚萜 耳草甙 6'-乙酰车叶草甙 

分 类 号：R284.2[医药卫生—中药学]