氨基葡萄糖苷酶的速率法测定及在临床中的应用研究  

Glucomsaminidase in Kinetic Rate Assay and Clinical Application

作　　者：段勇[1] 张秋霞[1] 王玉明[1] 周曾芬[1] 陈镇英[1] 段永寿[1] 

机构地区：[1]昆明医学院第一附属医院检验科

出　　处：《昆明医学院学报》1998年第1期1-4,共4页Journal of Kunming Medical College

摘　　要：检测了尿常规和血尿素氮、肌酐均正常的４４例肝硬化患者尿肌酐浓度和ＮＡＧ，ＧＡＬ，ＡＬＰ和ＧＧＴ的活性结果表明尿ＮＡＧ和ＡＬＰ活性明显高于正常对照组另外检测了１１６例病毒性肝炎患者血清ＮＡＧ活性，结果显示：急性肝炎组血清ＮＡＧ活性明显高于正常对照组（Ｐ＜０．０１）；而肝硬化组血清ＮＡＧ活性明显低于正常对照组（Ｐ＜００５）；多因素逐步回归统计分析表明血清中的ＮＡＧ与ＡＬＴ和ＧＧＴ呈正相关结果表明：（１）尿ＮＡＧ和ＡＬＰ活性测定可作为肝硬化早期肾损害的标志之一；Creatinine concetration as well as activities of NAG, GAL, ALP and GGT were deterimined in hepatic cirrhosis cases whose serum Bun, creatinine, and urinary analyses had proved to be normal. As a consequence, the NAG and ALP activities were significantly higher than those of the control group. Another NAG activity test was made in 116 patients with virus hepatitis and cirrhosis, whose serum NAG level, in contrast to that of the control group, was higher in the acute hepatitis group ( P <0.01) but lower in the cirrhosis group ( P <0.01). The stepwise regression analysis of multiple factors revealed a positive correlation among NAG, ALT and GGT. The results: 1) the assay of urinary NAG and ALP activities can be regarded as an index of the early renal injury for cirrhosis;2) the assay of serum NAG activity can served as a valuable index for the diagnosis of virus hepatitis and cirrhosis.

关 键 词：氨基葡萄糖苷酶 速率法 临床应用 

分 类 号：R446.112[医药卫生—诊断学]