20例畸胎弓形虫感染的检测  

Study on the Deformity of Fetus by Toxoplasma gondii Infection

作　　者：万明明[1,2] 陈艳[1,2] 王宝林[1,2] 毛克强[1,2] 裘学丽 陈景瑞[1,2] 郭丽萍 余士光[1,2] 夏良树 

机构地区：[1]贵阳医学院寄生虫学教研室 [2]贵阳医学院附院妇产科

出　　处：《贵阳医学院学报》1998年第1期35-36,共2页Journal of Guiyang Medical College

基　　金：贵州省科委资助"八五"攻关课题

摘　　要：采用ＤｏｔＥＬＩＳＡ检测血清中弓形虫循环抗原、循环抗体和动物接种分离虫体３种方法对贵阳地区２０例畸形胎儿及其母亲进行了弓形虫感染情况的检测。其中２例经动物接种分离出虫体，循环抗体、循环抗原的检测均呈阳性反应，被证实为先天性弓形虫病所致畸胎。致畸率为１０％，且均表现为中枢神经系统损害，一例为无脑儿，一例为脑积水。结果显示弓形虫感染是我省畸形胎儿的重要病因之一。he circular antigen and antibody of Toxoplasma gondii were detected in 20 sera of deformed fetus and their mother by DotELISA.Both circular antigen and antibody of Toxoplasma gondii were positive in two fetal sera and their mother.Tachyzoites of Toxoplasma gondii were isolated from the peritoneal fluid of CFW mice which were inoculated by these fetal liver,spleen,brain and lymphnode tissues.It confirms that these two deformed fetus are caused by congenital toxoplasmosis.The deforming rate was 10%.The deformity of one fetus was anencephalus and another was hydrocephalus.The results show that congenical toxoplasmasis is one of the important deforming factor in our province.

关 键 词：畸胎 弓形体病 斑点-酶联免疫吸附试验 

分 类 号：R531.8[医药卫生—内科学] R714.251[医药卫生—临床医学]