妊娠肝内胆汁淤积症患者血清一氧化氮和内皮素的变化及意义  

Changes and Significance of serum Nitric Oxide and Endothelin in Patients with Intrahepatic Cholestasis of Pregnancy

作　　者：腊晓琳[1] 郑美玉[1] 王冬梅[1] 

机构地区：[1]新疆医科大学第一附属医院妇产科,新疆乌鲁木齐830054

出　　处：《新疆医科大学学报》2002年第4期388-390,共3页Journal of Xinjiang Medical University

摘　　要：目的:探讨妊娠肝内胆汁淤积症 (ICP)患者外周静脉血清、新生儿脐静脉血清中一氧化氮 (NO)、内皮素 (ET)、丙二醛 (MDA)和超氧化物歧化酶 (SOD)含量的变化及在 ICP发病中的作用。方法:以 ICP组 2 8例为研究组 ,测定其外周静脉血清及新生儿脐静脉血清中的 NO、ET、MDA和 SOD,以年龄相近的 2 4例正常孕妇作为对照组。 结果 :ICP患者的 MDA和 ET含量较正常晚期妊娠显著增高 (P <0 .0 1) ,ICP患者的 NO和 SOD含量与对照组相比无显著性差异 (P >0 .0 5 )。母血清中 NO、ET、MDA含量均较新生儿脐静脉血清中的含量高 ,差异有显著性 (P <0 .0 1)。 结论 :妊娠期体内氧化和抗氧化失衡及 ET水平的增高可能与 ICP的发生。Objective: To study the changes and roles of nitric oxide (NO), endothelin (ET), superoxide dismutase (SOD) and malondialdehyde (MDA) in the pathogenesis of patients with intrahepatic cholestasis of pregnancy (ICP). Methods: The levels of NO, ET, MDA and SOD were measured in sera of peripheral blood of pregnant women with ICP and neonatal umbilical vein for 28 cases of the study group; 24 cases of normal pregnancy of similar age were used as control group. Results: The levels of ET and MDA in study group were higher than in control group (P<0.01), but the levels of NO and SOD were not significantly different between them. The maternal serum levels of NO, ET and MDA were higher than in neonatal umbilical vein in both groups (P<0.01). Conclusion: The imbalance between oxidation and anti oxidation and the increase of ET synthesis during pregnancy may play an important role in the pathogenesis of ICP.

关 键 词：肝内胆汁淤积 一氧化氮 内皮素 超氧化物歧化酶 丙二醛 妊娠并发症 

分 类 号：R714.255[医药卫生—妇产科学]