脂质过氧化抑制剂对大鼠肾脏低温保存的保护作用  

Protective effect of lipid peroxidation inhibitor on rat kidney during cold preservation

作　　者：润晓勤[1] 王春友[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院胰腺中心,武汉430022

出　　处：《腹部外科》2002年第6期360-361,共2页Journal of Abdominal Surgery

基　　金：国家自然科学基金资助项目 (3 9670 70 4)

摘　　要：目的　探讨脂质过氧化抑制剂预处理对大鼠肾脏低温保存的作用及其机制。方法　对低温保存的大鼠肾脏进行脂质过氧化抑制剂U74 0 0 6F的预处理 ,观察肾组织中脂质过氧化代谢产物丙二醛含量及诱导型一氧化氮合酶表达水平的变化。结果　U74 0 0 6F预处理可降低肾组织氧化反应水平 ,减少诱导性一氧化氮合酶的表达。结论　U74 0 0 6F预处理通过抑制细胞脂质过氧化减轻氧化反应和细胞因子带来的损伤 。Objective To investigate effect and mechanism of lipid peroxidation during kidney cold preservation. Methods Lipid peroxidation inhibitor U74006F was administrated prior to kidney harvest and cold preservation. Expressions of iNOS were detected by RT PCR. MDA concentration was also studied. Results Lipid peroxidation inhibitor administration was attended by a reduction in expression of iNOS. MDA in treated group was also reduced.Conclusions Lipid peroxidation inhibitor can reduce lipid peroxidation and have significant protection during renal cold preservation.

关 键 词：脂质过氧化抑制剂 大鼠 肾脏 低温保存 保护作用 

分 类 号：R692[医药卫生—泌尿科学] R977.9[医药卫生—外科学]