微生物发酵法制备梅岭霉素  

Preparation of Meilingmycin via Microbe Fermentation Method

作　　者：陈斌[1] 庄英萍[2] 储炬[2] 张嗣良[2] 

机构地区：[1]西北大学化工系 [2]华东理工大学生物反应器工程国家重点实验室国家生化工程技术研究中心

出　　处：《精细与专用化学品》2003年第1期17-19,共3页Fine and Specialty Chemicals

摘　　要：梅岭霉素与阿维菌素和伊维菌素具有相同的母核结构,并具有强烈的杀螨、杀虫和驱虫效果,其产业化研究已被列入国家“十五”攻关项目。梅岭霉素和南昌霉素都是南昌链霉素的发酵产物,经菌种选育,得到一种仅高产梅岭霉素的菌株。优化后的发酵水平在50L发酵罐中达到400ug/ml。通过对萃取条件的优化,梅岭霉素收率达到85％。Meilingmycin has the same nuclear parent structure as Avermectin and Ivermectin. It has strong acaricide-al, insecticidal and anthelmintic action. Research on commercialization of Meilingmycin has been ranked with the tenth five-yearkey program of China. Both Meilingmycin and Nanchangmycin are the fermentation products of Streptomyces nan-changensis, a high yielding strain which yield Meilingmycin only has been screened via cultivation. Optimized fermentation level has reached 400ug/ml in 50L fermenter. Meilingmycin can be reached 85% yield through optimizing extraction conditions.

关 键 词：微生物发酵法 制备 梅岭霉素 南昌链霉素 南昌霉素 阿维菌素 杀菌剂 

分 类 号：TQ459[化学工程—农药化工]