电化学发光微粒子免疫分析仪检测人绒毛膜促性腺激素β、糖类抗原125及雌二醇对先兆流产结局的预测价值  

Value of Detection ofβ-hCG,CA125 and E2 by Electrochemical Luminescence Microparticle Immunoassay for Threatened Abortion Outcome

作　　者：陈竟 CHEN Jing(Qianshan County People’s Hospital,Jiangxi Shangrao 334500)

机构地区：[1]铅山县人民医院,江西上饶334500

出　　处：《中国医疗器械信息》2024年第23期91-93,共3页China Medical Device Information

摘　　要：目的:探讨电化学发光微粒子免疫分析仪检测人绒毛膜促性腺激素β(β-hCG)、糖类抗原125(CA125)、雌二醇(E_(2))联合检测对先兆流产结局的预测价值。方法:选择2021年1月~2023年2月铅山县人民医院接诊的先兆流产产妇80例设为观察组,80例健康产妇作为对照组,采集3mL空腹肘正中静脉血,电化学发光微粒子免疫分析仪检测β-hCG、CA125、E_(2)水平。对比两组受检者β-hCG、CA125、E_(2),分析先兆流产不同妊娠结局者β-hCG、CA125、E_(2),并绘制受试者操作特征曲线。结果:观察组β-hCG、E_(2)检测值低于对照组,CA125检测值较对照组高(P<0.05)。先兆流产患者中妊娠失败21例,继续妊娠59例。妊娠失败者β-hCG、E_(2)检测值低于继续妊娠者,CA125检测值较继续妊娠者高(P<0.05)。β-hCG、CA125、E_(2)联合检测对先兆流产结局的预测的曲线下面积为0.936,敏感度为94.90%,特异度为76.20%,均高于单一检测。结论:电化学发光微粒子免疫分析仪检测β-hCG、CA125、E_(2)均是预测先兆流产结局的有效指标,三者联合检测能提高预测准确性。Objective:To investigate the predictive value of human chorionic gonadotropin(β-hCG),glycoprotein 125(CA125)and estradiol(E_(2))combined detection by electrochemical luminescence microparticle immunoassay in the outcome of threatened abortion.Methods:A total of 80 pregnant women with threatened abortion who were admitted to Qianshan County People’s Hospital from January 2021 to February 2023 were selected as the observation group,and 80 healthy women were selected as the control group.3mL fasting median elbow venous blood was collected,andβ-hCG,CA125 and E_(2) were detected by electrochemiluminescence microparticle immunoassay.Theβ-hCG,CA125 and E_(2) of the two groups were compared,and theβ-hCG,CA125 and E_(2) of the patients with different pregnancy outcomes of threatened abortion were analyzed,and the receiver operating characteristic curve was drawn.Results:Theβ-hCG and E_(2) values in the observation group were lower than those in the control group,and the CA125 values were higher than those in the control group(P<0.05).Of the patients with threatened abortion,21 had pregnancy failure and 59 continued pregnancy.The test values ofβ-hCG and E_(2) in pregnant losers were lower than those in pregnant women,and the test values of CA125 were higher than those in pregnant women(P<0.05).The combined detection ofβ-hCG,CA125 and E_(2) predicted the outcome of threatened abortion with an area under the curve(AUC)of 0.936,a sensitivity of 94.90%and a specificity of 76.20%,all of which were higher than that of single detection.Conclusion:The detection ofβ-hCG,CA125,and E_(2) by electrochemiluminescence particle immunoassay analyzer is an effective indicator for predicting the outcome of threatened miscarriage.The combined detection of the three can improve the accuracy of prediction.

关 键 词：先兆流产 人绒毛膜促性腺激素 妊娠结局 糖类抗原125 雌二醇 

分 类 号：R446.1[医药卫生—诊断学]