硫化氢供体型灯盏乙素衍生物的设计与合成  

Design and Synthesis of Scutellarin Derivatives Bearing a Hydrogen Sulfide Donors

作　　者：贾新博 柳旭 王梦希 姚元也 郭美彤 顾宇 张景 张烁 姜春宇 韩通 JIA Xinbo;LIU Xu;WANG Mengxi;YAO Yuanye;GUO Meitong;GU Yu;ZHANG Jing;ZHANG Shuo;JIANG Chunyu;HAN Tong(Department of Pharmaceutical Engineering,Heilongjiang Bayi Agricultural University,Daqing 163319,China)

机构地区：[1]黑龙江八一农垦大学制药工程系,黑龙江大庆163319

出　　处：《山东化工》2024年第22期84-86,共3页Shandong Chemical Industry

基　　金：黑龙江省大学生创新训练项目(S202210223069);黑龙江八一农垦大学学成引进人才科研启动计划(XYB2018-14)。

摘　　要：本研究以灯盏乙素为先导化合物,在其结构中的B环4'-OH和A环6-OH处进行甲基化,获得甲基化中间体3。硫化氢供体ADT-OH与TBZ分别与1,2-二溴乙烷和1,5-二溴戊烷反应得到中间体6a, 6b, 8a和8b。3与6a, 6b, 8a和8b反应得到4个硫化氢供体型灯盏乙素衍生物10a, 10b, 11a和11b。目标化合物的结构经过~1H-NMR确证。In this paper,scutellarin was used as the lead compound and methylated at B ring 4'-OH and A ring 6-OH to obtain methylation intermediate 3.The hydrogen sulfide donor ADT-OH and TBZ reacted with 1,2-dibromoethane and 1,5-dibromopentane,respectively,to obtain intermediates 6a,6b,8a and 8b.3 reacts with 6a,6b,8a,and 8b to produce four scutellarin derivatives bearing a hydrogen sulfide donor 10a,10b,11a,and 11b.The structure of the target compound was confirmed by 1H-NMR.

关 键 词：灯盏乙素 硫化氢供体 合成 

分 类 号：TQ460[化学工程—制药化工]