过渡金属配合物作为光敏剂在光动力治疗中的研究与应用  

Research and Application of Transition Metal Complexes as Photosensitizers in Photodynamic Therapy

作　　者：余兴粉 YU Xingfen(College of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650000,China)

机构地区：[1]云南师范大学化学化工学院,云南昆明650000

出　　处：《山东化工》2024年第22期122-124,127,共4页Shandong Chemical Industry

摘　　要：作为一种新兴的无创治疗方法,光动力治疗在癌症治疗方面具有副作用小、累积毒性小、有效杀伤肿瘤以及精准的靶向治疗而不损伤邻近组织等优势,是理想的癌症治疗方法之一。过渡金属配合物作为一种光敏剂,已被证实在光动力疗法中可以很好地治疗肿瘤与癌症。这篇文章主要综述了光动力治疗的原理、基本要素和细胞作用的机制,最后例举了金属铱(Ir)、钌(Ru)配合物作为一种光敏剂在光动力治疗中的研究与其在医学领域的应用。As an emerging non-invasive treatment,photodynamic therapy is one of the ideal cancer treatments due to its advantages of low side effects,low cumulative toxicity,effective tumor killing,and precise targeted therapy without damaging adjacent tissues.As photosensitizers,transition metal complexes have been shown to be effective in the treatment of tumors and cancers in photodynamic therapy.This article mainly reviews the principles,basic elements and mechanisms of cellular action of photodynamic therapy,and finally gives an example of the research of iridium(Ir)and ruthenium(Ru)complexes as photosensitizers in photodynamic therapy and their application in the medical field.

关 键 词：过渡金属配合物 光敏剂 光动力治疗 

分 类 号：O641[理学—物理化学]