天然产物川陈皮素的成分差异及抗肿瘤作用机制研究进展  

Research Progress on Compositional Differences and Anti-Tumor Effect Mechanism of Nobiletin

作　　者：辛力 龚文慧 郭静英 郑郁清 赵蓓蓓 严世豪 张文 张金莲[1] XIN Li;GONG Wenhui;GUO Jingying;ZHENG Yuqing;ZHAO Beibei;YAN Shihao;ZHANG Wen;ZHANG Jinlian(Jiangxi University of Chinese Medicine,Nanchang 330004,Jiangxi,China)

机构地区：[1]江西中医药大学,江西南昌330004

出　　处：《中华中医药学刊》2025年第1期191-195,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82060724,81560651);江西省中医药标准委员会第二批标准化项目(2021B01,2021B02);江西中医药大学大学生创新创业训练计划项目(202310412027,S202310412061,202210412288)。

摘　　要：随着天然药物化学不断地发展,植物中具有良好活性的天然产物逐渐受到人们的关注,但大多由于含量较低等限制了进一步开发,如何提高含量,确保天然来源的质量,成为了迫在眉睫的问题。川陈皮素是一种天然的多甲氧基黄酮类成分,主要存在于芸香科柑橘属植物中,具有抗肿瘤、抗炎、保护及改善神经系统等广泛的生物活性,因其可通过多途径抗多种癌细胞的广谱抗癌作用,逐渐成为抗肿瘤新药开发的热点。通过查阅文献,总结近年来国内外对于川陈皮素的研究,概括研究现状,从不同来源、产地、贮藏、炮制等方面对川陈皮素含量的影响因素及其抗肿瘤作用机制进行总结归纳,明确天然来源的质量控制方法,旨在为川陈皮素的进一步研究开发及抗肿瘤新药研发提供参考。With the continuous development of natural medicinal chemistry,natural products with good activity in plants are gradually attracting attention,but most of them are restricted from further development due to their low content,etc.How to increase the content and ensure the quality of natural sources has become an urgent issue.Nobiletin is a natural polymethoxyflavonoid,mainly exists in Citrus aurantium,family Rutaceae,with a wide range of biological activities such as anti-tumor,anti-inflammatory,protection and improvement of the nervous system,etc.It has gradually become a hot spot for the development of new anti-tumor drugs for its broad spectrum anti-cancer effects against a variety of cancer cells through multiple pathways.Through reviewing the literature,summarizing the research on nobiletin at home and abroad in recent years,and outlining the current status of research,this paper summed up the factors influencing the content of nobiletin and its antitumor mechanism of action from different sources,origins,storage and concoction,and clarified the quality control methods of natural sources,aiming to provide new ideas for further research and development of nobiletin and new antitumor drugs.

关 键 词：川陈皮素 天然产物 多甲氧基黄酮 抗肿瘤 

分 类 号：R284.1[医药卫生—中药学]