胡氏益胃汤结合针刺疗法治疗慢性萎缩性胃炎临床观察  

Clinical Observation on Treatment of Chronic Atrophic Gastritis by Hushi Yiwei Decoction(胡氏益胃汤)Combined with Acupuncture

作　　者：李海涛 张晓明 郭婷婷 鄢雪辉 利小华 LI Haitao;ZHANG Xiaoming;GUO Tingting;YAN Xuehui;LI Xiaohua(Jinhua Hospital of Traditional Chinese Medicine,Jinhua 321017,Zhejiang,China)

机构地区：[1]金华市中医医院,浙江金华321017

出　　处：《中华中医药学刊》2025年第1期200-203,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(20212B318)。

摘　　要：目的观察胡氏益胃汤结合针刺疗法治疗慢性萎缩性胃炎临床效果和安全性。方法纳入104例慢性萎缩性胃炎患者(2021年1月—2023年6月收治)进行分组研究,分组方法为随机数字表法,将其随机分为对照组与中医组,给予对照组患者(52例)西药(呋喃唑酮片、西沙比利片)治疗,中医组在对照组西药治疗基础上结合胡氏益胃汤以及针刺疗法治疗,研究过程中中医组脱落3例,对照组脱落1例。观察各组患者临床数据情况:疗效、治疗前后中医证候积分(胃脘痞闷及反酸嗳气、腹痛胀满)变化及胃镜指标(肠化程度、胃黏膜特征以及胃萎缩程度)评分变化、血清胃肠激素指标(胃动力素以及生长抑制素胃泌素)变化、白介素-6(Interleukin-6,IL-6)及白介素-8(Interleukin-8,IL-8)、肿瘤坏死因子α(Tumour necrosis factor-α,TNF-α)等血清炎性因子水平变化、治疗前后幽门螺杆菌(HP)阳性率变化、T淋巴细胞(Human lymphocyte CD_(4)^(+),human lymphocyte CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+))变化、不良反应。结果中医组患者治疗效果优于对照组(P<0.05);治疗前各组患者中医证候积分(胃脘痞闷及反酸嗳气、腹痛胀满)、胃镜指标(肠化程度、胃黏膜特征以及胃萎缩程度)评分、血清胃肠激素指标(胃动力素以及生长抑制素、胃泌素)、血清炎性因子水平(IL-6、IL-8及TNF-α)、HP阳性率、免疫功能指标(CD_(4)^(+)、CD_(8)^(+)、CD_(4)^(+)/CD_(8)^(+))比较,P>0.05,治疗后各组患者中医证候积分(胃脘痞闷及反酸嗳气、腹痛胀满)及胃镜指标(肠化程度、胃黏膜特征以及胃萎缩程度)评分、胃泌素水平、IL-6、IL-8及TNF-α水平、HP阳性率、CD_(8)^(+)指标均下降,胃动力素以及生长抑制素水平、CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)指标均上升,中医组治疗后各项指标上升及下降程度均大于对照组患者(均P<0.05);中医组与对照组不良反应率均较低(P>0.05)。结论胡氏益胃汤结合�Objective To observe the clinical effect and safety of Hushi Yiwei Decoction(胡氏益胃汤)combined with acupuncture in the treatment of chronic atrophic gastritis.Methods A total of 104 patients with chronic atrophic gastritis(admitted from January 2021 to June 2023)were included for group study.The patients were randomly divided into control group(Furazolidone Tablets and Cisaprid Tablets)and traditional Chinese medicine group(Furazolidone Tablets and Cisaprid Tablets,Hushi Yiwei Decoction and acupuncture)by random number table method,and 52 cases in each group.During the study,3 cases fell off in the traditional Chinese medicine group and 1 case fell off in the control group.The effect,the changes of TCM syndrome scores(epigastric fullness,stomachache and distention)and gastroscopy indexes(degree of enterization,gastric mucosa characteristics and degree of gastric atrophy)before and after treatment,the levels of serum gastrointestinal hormone indexes(gastrin and somatostatin gastrin),the levels of serum inflammatory factors[interleukin-6(IL-6),interleukin-8(IL-8),tumour necrosis factor-α(TNF-α)],the positive rates of Helicobacter pylori(HP)before and after treatment,the levels of T lymphocytes(CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+))and adverse reactions were observed.Results The treatment effect of the traditional Chinese medicine group was better than that of the control group(P<0.05).Before treatment,TCM syndrome scores(gastric epigastric fullness and acid belching,abdominal pain and distension),gastroscopy indexes(degree of enterization,gastric mucosa characteristics and degree of gastric atrophy),serum gastrointestinal hormone indexes(motilin,somatostatin and gastrin),serum inflammatory factor levels(IL-6,IL-8 and TNF-α),HP positive rate and immune function indexes(CD_(4)^(+),CD_(8)^(+),CD_(4)^(+)/CD_(8)^(+))of all patients in each group were not significant(P>0.05).After treatment,TCM syndrome scores(gastric epigastric fullness,acid belching,abdominal pain and distention),gastroscopy indexes(deg

关 键 词：慢性萎缩性胃炎 针刺疗法 胡氏益胃汤 疗效 免疫功能 幽门螺杆菌 不良反应 

分 类 号：R245.31[医药卫生—针灸推拿学] R259.733.2[医药卫生—中医临床基础]