麻杏石甘汤联合阿莫西林钠克拉维酸钾对肺部感染患儿炎症指标的影响  

Effect of Maxing Shigan Decoction(麻杏石甘汤)Combined with Amoxicillin Sodium and Clavulanate Potassium on Inflammatory Indexes in Children with Pulmonary Infection

作　　者：王毅杰 李晓辉[2] 吴俊 钟志强 WANG Yijie;LI Xiaohui;WU Jun;ZHONG Zhiqiang(Lishui Hospital of Traditional Chinese Medicine,Lishui 323000,Zhejiang,China;Rizhao Hospital of Traditional Chinese Medicine,Rizhao 276800,Shandong,China)

机构地区：[1]丽水市中医院,浙江丽水323000 [2]日照市中医医院,山东日照276800

出　　处：《中华中医药学刊》2025年第1期210-213,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：浙江省中医药科技计划项目(2022ZA188)。

摘　　要：目的观察麻杏石甘汤联合阿莫西林钠克拉维酸钾治疗肺部感染患儿的临床疗效以及对炎症等指标影响。方法研究总计纳入肺部感染患儿85例,患儿均由医院儿科2020年12月—2023年2月收治,符合肺部感染诊断,以随机数字表法将患儿分为对照组(42例)与观察组(43例),给予对照组患儿阿莫西林钠克拉维酸钾治疗,给予观察组患儿阿莫西林钠克拉维酸钾结合麻杏石甘汤治疗,治疗过程中对照组脱落1例,观察组脱落2例,观察各组患儿数据:患儿治疗效果、发热消失时间、肺部感染吸收时间、止咳时间、心率呼吸复常时间与肺部啰音消失时间、治疗前后患儿中医证候(咳嗽、气喘、咳痰、发热、烦躁不安等)积分变化、炎症因子指标变化与肺功能指标变化、氧合指数与肺部感染评分变化、住院时间与医疗费用、治疗不良反应。结果观察组患儿治疗效果优于对照组患儿(P<0.05);较对照组患儿,观察组患儿的发热消失时间、肺部感染吸收时间、止咳时间、心率呼吸复常时间与肺部啰音消失时间均更短(P<0.05);治疗前各组患儿中医证候(咳嗽、气喘、咳痰、发热、烦躁不安等)积分、肿瘤坏死因子α(Tumour necrosis factor-α,TNF-α)与白介素-6(Interleukin 6,IL-6)、白介素-8(Interleukin 8,IL-8)等炎症因子指标、用力肺活量(Forced vital capacity,FVC)与第1秒用力呼气容积(Forced expiratory volume in one second,FEV1)等肺功能指标、氧合指数与肺部感染评分比较,P>0.05,治疗后各组患儿中医证候(咳嗽、气喘、咳痰、发热、烦躁不安等)积分、炎症因子指标(TNF-α、IL-6及IL-8)、肺功能指标(FVC及FEV1)、氧合指数与肺部感染评分等指标均改善,观察组患儿治疗后中医证候(咳嗽、气喘、咳痰、发热、烦躁不安等)积分、炎症因子指标(TNF-α、IL-6及IL-8)、肺功能指标(FVC及FEV1)、氧合指数与肺部感染评分等指标均优于对照组患儿(Objective To observe the clinical effect of Maxing Shigan Decoction(麻杏石甘汤)combined with amoxicillin sodium and clavulanate potassium in the treatment of children with pulmonary infection and its influence on inflammation and other indicators.Methods A total of 85 children with pulmonary infection were included in the study,all of whom were admitted to the Department of Pediatrics of the hospital from December 2020 to February 2023,meeting the diagnosis of pulmonary infection.The children were divided into control group(42 cases)and observation group(43 cases)by random number table method,and the control group was treated with amoxicillin sodium and clavulanate potassium.The children in the observation group were treated with amoxicillin sodium clavulanate potassium combined with Maxing Shigan Decoction.During the treatment,1 case fell off in the control group and 2 cases fell off in the observation group.The data of children in each group was observed,including treatment effect,fever disappearance time,lung infection absorption time,cough relief time,heart rate respiratory recovery time and the time of disappearance of lung rales,the scores of traditional Chinese medicine symptoms(cough,asthma,expectoration,fever,irritability,etc.)changes before and after treatment,changes of inflammatory factor indicators and lung function indicators,changes of oxygenation index and lung infection score,length of hospital stay and adverse reactions.Results The treatment effect of the observation group was better than that of control group(P<0.05).Compared with those of the control group,the disappearance time of fever,absorption time of pulmonary infection,cough relief time,heart rate and respiration recovery time and the disappearance time of lung rales in observation group were shorter(P<0.05).The levels of tumor necrosis factor-α(TNF-α),interleukin 6(IL-6),interleukin 8(IL-8)and other inflammatory markers,the scores of TCM symptoms(cough,asthma,phlegm,fever,irritability,etc.)in each group before treatment,forced v

关 键 词：肺部感染 患儿 麻杏石甘汤 阿莫西林钠克拉维酸钾 疗效 炎症指标 不良反应 

分 类 号：R259.631[医药卫生—中西医结合]