柴胡清上汤联合凝视稳定性前庭康复训练对前庭神经炎前庭功能和氧化应激的影响  

Effects of Chaihu Qingshang Decoction(柴胡清上汤)Combined with Gaze Stability Vestibular Rehabilitation Training on Vestibular Function and Oxidative Stress in Patients with Vestibular Neuritis

作　　者：李得平 苗治国 李振 龚晓强 刘博 LI Deping;MIAO Zhiguo;LI Zhen;GONG Xiaoqiang;LIU Bo(Zhengzhou Traditional Chinese Medicine Hospital,Zhengzhou 450007,Henan,China)

机构地区：[1]郑州市中医院,河南郑州450007

出　　处：《中华中医药学刊》2025年第1期226-230,共5页Chinese Archives of Traditional Chinese Medicine

基　　金：河南省卫生健康委员会中医药管理局中医药专项(2022ZY2063)。

摘　　要：目的探讨柴胡清上汤联合凝视稳定性前庭康复训练对前庭神经炎患者前庭功能和氧化应激的影响。方法选择2021年7月—2022年12月医院就诊并诊断为前庭神经炎患者60例作为研究对象,随机分为试验组和对照组,各30例。对照组予以常规及对症治疗,试验组在对照组基础上予以柴胡清上汤联合凝视稳定性前庭康复训练。比较治疗前后两组患者临床疗效、眩晕症状评定量表(Vertigo symptom rating scale,DARS)、眩晕障碍量表(Dizziness handicap inventory,DHI)及特异性活动平衡自信量表(Activities-specific balance confidence scale,ABC)、前庭功能、血清炎症因子、氧化应激指标及不良反应发生情况。结果治疗后,与对照组总有效率63.33%(19/30)相比,试验组总有效率(86.67%,26/30)较高(P<0.05),与治疗前比较,两组患者DARS、DHI评分均显著降低,ABC评分升高(P<0.05);治疗后与对照组相比,试验组DARS、DHI评分较低,ABC评分较高(P<0.05)。与治疗前比较,两组患者半规管轻瘫(Semicircular canal paraplegia,CP)值、扫视波幅度、自发眼震强度、摇头眼震强度明显下降,半规管增益明显增高(P<0.05);治疗后与对照组相比,试验组半规管轻瘫CP值、扫视波幅度、自发眼震强度、摇头眼震强度较低,半规管增益较高(P<0.05)。与治疗前比较,两组患者血清肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、白细胞介素-6(Interleukin-6,IL-6)水平明显下降(P<0.05);且与对照组相比,试验组血清TNF-α、IL-6水平较低(P<0.05)。与治疗前比较,两组患者超氧化物歧化酶(Superoxide dismutase,SOD)水平明显升高,丙二醛(Malondialdehyde,MDA)水平降低(P<0.05);且与对照组相比,试验组SOD水平较高,MDA水平较低(P<0.05)。两组不良反应发生情况相比差异无统计学意义(P>0.05)。结论柴胡清上汤联合凝视稳定性前庭康复训练可有效提升前庭神经炎患者整体治疗效果,调节机体内血清炎症、氧化Objective To explore the effect of Chaihu Qingshang Decoction(柴胡清上汤)combined with gaze stability vestibular rehabilitation training on vestibular function and oxidative stress in patients with vestibular neuritis.Methods Sixty patients with vestibular neuritis who were diagnosed in the hospital from July 2021 to December 2022 were selected as research objects,and were randomly divided into the experiment group and the control group,with 30 patients in each group.The control group was given routine and symptomatic treatment,and the experiment group was given Chaihu Qingshang Decoction combined with gaze stability vestibular rehabilitation training on the basis of the control group.The clinical efficacy,dizziness symptom assessment scale,dizziness disorder scale,specific activity balance confidence scale,vestibular function,serum inflammatory factors,oxidative stress indicators and incidence of adverse reactions were compared between the two groups before and after treatment.Result After treatment,compared with the total effective rate(63.33%,19/30)in the control group,the total effective rate(86.67%,26/30)in the experimental group was higher(P<0.05).Compared with those before treatment,the Vertigo Symptom Rating Scale(DARS)and Dizziness Handicap Inventory(DHI)scores of both groups were significantly reduced,while the activities-specific balance confidence scale(ABC)scores were increased(P<0.05).After treatment,compared with the control group,the experimental group had lower DARS and DHI scores,and higher ABC scores(P<0.05).Compared with that before treatment,semicircular canal paresis(CP)value,scanning wave amplitude,spontaneous nystagmus intensity and shaking head nystagmus intensity of semicircular canals paresis patients in the two groups decreased significantly,and semicircular canals gain increased significantly(P<0.05).After treatment,compared with those of the control group,the CP value,scanning wave amplitude,spontaneous nystagmus intensity and shaking head nystagmus intensity of semicircular can

关 键 词：柴胡清上汤 凝视稳定性前庭康复训练 前庭神经炎 前庭功能 氧化应激 

分 类 号：R277.745[医药卫生—中医学]