血清CKAP4、CTRP9对维持性血液透析患者发生血管钙化的预测价值  

Predictive value of serum CKAP4 and CTRP9 on vascular calcification in maintenance hemodialysis patients

作　　者：张胜楠 高志超 林彬 刘丽萍 ZHANG Shengnan;GAO Zhichao;LIN Bin;LIU Liping(Hemodialysis Room,Beijing Longfu Hospital,Beijing 100010,China;Department of Nephrology,Beijing Longfu Hospital,Beijing 100010,China)

机构地区：[1]北京市隆福医院血液透析室,北京100010 [2]北京市隆福医院肾内科,北京100010

出　　处：《检验医学与临床》2025年第1期61-65,共5页Laboratory Medicine and Clinic

基　　金：北京市隆福医院院内课题(LFYYKT-2022-21)。

摘　　要：目的分析细胞骨架相关蛋白4(CKAP4)、补体C1q肿瘤坏死因子相关蛋白9(CTRP9)对维持性血液透析(MHD)患者发生血管钙化的预测价值。方法选取2021年4月至2023年6月该院收治的132例MHD患者作为研究对象,根据血管钙化总评分将其分为钙化组、非钙化组,另选取同期在该院体检的62例健康人群作为对照组。比较钙化组、非钙化组、对照组一般资料及血清CKAP4、CTRP9水平,比较钙化组和非钙化组临床资料。采用Pearson相关分析MHD患者血清CKAP4、CTRP9水平与钙磷代谢相关指标的相关性。采用多因素Logistic回归分析MHD患者发生血管钙化的影响因素。绘制受试者工作特征(ROC)曲线分析MHD患者发生血管钙化的预测价值。结果非钙化组和钙化组患者血清CKAP4、CTRP9水平低于对照组,且钙化组低于非钙化组,差异均有统计学意义(P<0.05)。钙化组血钙、血磷、甲状旁腺激素(PTH)水平高于非钙化组,差异均有统计学意义(P<0.05)。Pearson相关分析结果显示,MHD患者血清CKAP4、CTRP9水平与血钙、血磷、PTH水平呈负相关(P<0.05)。多因素Logistic回归分析结果显示,血清CKAP4、CTRP9水平降低是MHD患者发生血管钙化的危险因素(P<0.05)。ROC曲线分析结果显示,血清CKAP4、CTRP9联合预测患者发生血管钙化的曲线下面积大于各项指标单独预测(Z_(2项联合-CKAP4)=2.307、P=0.021;Z_(2项联合-CTRP9)=2.484、P=0.013)。结论MHD患者血清CKAP4、CTRP9水平明显降低,2项指标联合对MHD患者发生血管钙化的预测价值高于单项指标。Objective To analyze the predictive value of cytoskeletal-associated protein 4(CKAP4)and complement C1q tumour necrosis factor related protein 9(CTRP9)on vascular calcification in maintenance hemodialysis(MHD)patients.Methods A total of 132 MHD patients admitted to the hospital from April 2021 to June 2023 were selected as the research subjects,and they were divided into the calcification group and the non-calcification group according to the total vascular calcification score,and 62 healthy people who underwent physical examination in the hospital during the same period were selected as the control group.The general data and serum CKAP4 and CTRP9 levels of the calcification group and the non-calcification group and the control group were compared,and the clinical data of the calcification group and the non-calcification group were compared.Pearson correlation was used to analyze the correlation between serum CKAP4,CTRP9 levels and related indexes of calcium and phosphorus metabolism in MHD patients.Multivariate Logistic regression was used to analyze the influencing factors of vascular calcification in MHD patients.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of vascular calcification in MHD patients.Results Serum CKAP4 and CTRP9 levels in the non-calcification group and the calcification group were lower than those in the control group,and those in the calcification group were lower than those in the non-calcification group,and the differences were statistically significant(P<0.05).The levels of calcium,phosphorus and parathyroid hormone(PTH)in the calcification group were higher than those in the non-calcification group,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the serum levels of CKAP4 and CTRP9 were negatively correlated with the serum levels of calcium,phosphorus and PTH in MHD patients(P<0.05).Multivariate Logistic regression analysis showed that the decrease of serum CKAP4 and CTRP9 levels were risk factors

关 键 词：维持性血液透析 细胞骨架相关蛋白4 补体C1q肿瘤坏死因子相关蛋白9 血管钙化 

分 类 号：R692.5[医药卫生—泌尿科学] R446.1[医药卫生—外科学]