血栓弹力图与儿童脓毒症3.0评分标准的相关性  

Correlation between thrombelastogram and pediatric sepsis 3.0 scoring criteria

作　　者：吴春友 刘青青 谭丽娜 苏永红[1] WU Chunyou;LIU Qingqing;TAN Lina;SU Yonghong(Weifang Maternal and Child Health Hospital,Weifang 261000,China)

机构地区：[1]潍坊市妇幼保健院,山东潍坊261000

出　　处：《临床医学研究与实践》2024年第36期66-69,共4页Clinical Research and Practice

基　　金：潍坊市2021年科学技术发展计划(医学类)项目(No.2021YX052)。

摘　　要：目的探讨血栓弹力图(TEG)与儿童脓毒症3.0评分标准的相关性。方法回顾性分析2021年1月至2023年12月潍坊市妇幼保健院PICU收治的51例脓毒症患儿的相关病例资料,根据菲尼克斯脓毒症评分(PSS)将其分为脓毒症组(n=40)和脓毒性休克组(n=11)。入院后24 h内完成血常规、TEG检测及PSS评分。比较两组的TEG指标;采用Spearman相关性分析探究TEG各指标与PSS评分的相关性。结果脓毒症组的PSS评分低于脓毒性休克组,差异具有统计学意义(P<0.05)。脓毒症组的凝血反应时间(R)、血凝块形成时间(K)短于脓毒性休克组,α角、血凝块最大强度(MA)及凝血综合指数(CI)高于对照组,差异具有统计学意义(P<0.05)。Spearman相关性分析结果显示,PSS评分与R、K呈正相关(r=0.908、0.681,P<0.001);PSS评分与α角、MA、CI呈负相关(r=-0.869、-0.690、-0.901,P<0.001)。结论TEG与儿童脓毒症PSS评分有明确相关性,具有预估脓毒症患儿病情严重程度的参考价值,对脓毒性休克患儿的病情有一定的预判性,对提前制定干预措施,提高抢救成功率有一定的意义。Objective To investigate the correlation between thromboelastogram(TEG)and pediatric sepsis 3.0 scoring criteria.Methods The clinical data of 51 children with sepsis admitted to PICU of Weifang Maternal and Child Health Hospital from January 2021 to December 2023 were retrospectively analyzed.According to the Phoenix Sepsis Score(PSS),the children were divided into sepsis group(n=40)and septic shock group(n=11).Routine blood test,TEG test and PSS score were completed within 24 h after admission.The TEG indexes of the two groups were compared;Spearman correlation analysis was used to explore the correlation between TEG indicators and PSS scores.Results The PSS score of the sepsis group was lower than that of the septic shock group,and the difference was statistically significant(P<0.05).The reaction time(R)and kinetics time(K)of the sepsis group were shorter than those of the septic shock group,and theαangle,maximum amplitude(MA)and coagulation index(CI)were higher than those of the control group,the differences were statistically significant(P<0.05).Spearman correlation analysis showed that PSS score was positively correlated with R and K(r=0.908,0.681,P<0.001);PSS score was negatively correlated withαangle,MA and CI(r=-0.869,-0.690,-0.901,P<0.001).Conclusion TEG has a clear correlation with PSS score of sepsis in children,and has a reference value for predicting the severity of sepsis in children.It has a certain predictive value for the condition of children with septic shock,and has certain significance for formulating intervention measures in advance and improving the success rate of rescue.

关 键 词：脓毒症 脓毒性休克 血栓弹力图 菲尼克斯脓毒症评分 

分 类 号：R459.7[医药卫生—急诊医学]