老年病人记忆能力相关的脑电非线性分析研究  

Study on nonlinear analysis of EEG related to memory ability in elderly patients

作　　者：尹鹏程 王鑫智 张林忠[2] YIN Pengcheng;WANG Xinzhi;ZHANG Linzhong(School of Anesthesiology,Shanxi Medical University,Taiyuan 030001,China;Department of Anesthesiology,Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学麻醉学院,山西省太原市030001 [2]山西医科大学第二医院麻醉科,山西省太原市030001

出　　处：《实用老年医学》2025年第1期61-65,共5页Practical Geriatrics

基　　金：山西省回国留学人员科研资助项目(2021-170)。

摘　　要：目的探讨择期行全麻手术的老年病人术前与术后脑电非线性动力学参数变化规律,及其在记忆能力研究中的作用。方法选取全麻下行择期非心脏手术治疗的老年病人,随机分为有麻醉深度监测组(A组)和无麻醉深度监测组(N组)。采集2组病人手术前后休息状态和记忆任务状态下的脑电信号,对2组脑电非线性分析指数(关联维数和近似熵)进行比较分析。采用记忆与执行筛查量表(MES)对病人术前、术后的记忆能力进行测评和比较。结果术前2组病人休息状态、记忆任务状态下的关联维数和近似熵差异均无统计学意义(P>0.05);术后1 d,2组两种状态下的关联维数和近似熵均下降,但A组均高于N组,差异有统计学意义(P<0.05)。2组病人术前MES评分比较,差异无统计学意义(P>0.05)。术后1 d,2组病人MES评分均下降(P<0.05),但A组高于N组(P<0.05)。结论对于老年病人来说,全麻手术后可能出现脑电非线性分析指数结果下降和短期记忆能力下降,尤其是术中无麻醉深度监测的病人下降更明显。Objective To explore the changes of nonlinear dynamic parameters of electroencephalogram(EEG)before and after operation in the elderly patients undergoing elective general anesthesia,and to investigate its role in the study of memory capacity.Methods The elderly patients undergoing elective non-cardiac surgery under general anesthesia were randomly divided into group with anesthesia depth monitoring(group A)and group without anesthesia depth monitoring(group N).The EEG signals of the two groups of patients before and after operation in rest state and memory task state were collected,and the nonlinear analysis index including correlation dimension and approximate entropy of the two groups of patients were compared and analyzed.The memory and execution screening scale(MES)was used to evaluate the memory ability of patients before and after operation.Results One day before operation,there was no significant difference in correlation dimension and approximate entropy between the two groups in rest state and memory task state(P>0.05);On the first day after surgery,the correlation dimension and approximate entropy decreased in both groups in both states,but the indexes in group A were higher than those in group N,and the difference was statistically significant(P<0.05).There was no significant difference in MES score between the two groups 1 day before operation(P>0.05).On the first day after operation,the MES score in both groups decreased(P<0.05),but the score of group A was higher than that of group N(P<0.05).Conclusions For elderly patients,there may be a decrease in EEG nonlinear analysis index and short-term memory ability after general anesthesia surgery,especially in patients without intraoperative anesthesia depth monitoring.

关 键 词：记忆 脑电图 非线性分析 老年人 

分 类 号：R614[医药卫生—麻醉学]