补中益气汤加减联合穴位敷贴治疗膀胱过度活动症的临床研究  

Modified Buzhong Yiqi Decoction combined with acupoint application in treatment of patients with overactive bladders

作　　者：杜伟 廖土明 吴佳桥 李雄才 朱和荣 何燊 关刚强 Du Wei;Liao Tuming;Wu Jiaqiao;Li Xiongcai;Zhu Herong;He Shen;Guan Gangqiang(Department of Urology,Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Foshan 528200,China)

机构地区：[1]广东省中西医结合医院泌尿外科,佛山528200

出　　处：《国际医药卫生导报》2025年第2期274-278,共5页International Medicine and Health Guidance News

基　　金：广东省中医药局科研立项课题(20232016)。

摘　　要：目的探讨补中益气汤加减联合穴位敷贴治疗膀胱过度活动症(OAB)的效果。方法回顾性分析,选取2022年1月至2024年3月在广东省中西医结合医院泌尿外科治疗的女性OAB患者91例作为研究对象,通过随机数字表法分为试验组(30例)、对照组1(30例)、对照组2(31例)。试验组年龄(46.72±10.13)岁,病程(3.09±2.49)年,口服补中益气汤加减联合穴位敷贴治疗;对照组1年龄(46.98±11.29)岁,病程(3.18±2.63)年,口服琥珀酸索利那新片治疗;对照组2年龄(47.48±10.11)岁,病程(3.08±2.44)年,口服补中益气汤加减治疗。均连续用药12周。对比3组患者治疗前、治疗12周后的排尿日记情况(白天排尿次数、夜尿次数、24 h尿急、24 h急迫性尿失禁)、生活质量评分、膀胱过度活动症状评分(OABSS)、临床疗效与不良反应情况。统计学方法采用t检验、χ^(2)检验。结果治疗前及治疗12周后,试验组患者白天排尿次数、夜尿次数、24 h尿急、24 h急迫性尿失禁、OABSS及生活质量评分分别为(14.4±1.57)次、(3.5±0.71)次、(3.5±0.53)次、(2.5±0.53)次、(9.7±1.16)分、(3.9±0.88)分,(10.1±1.10)次、(2.1±0.57)次、(1.9±0.57)次、(1.2±0.42)次、(4.4±1.26)分、(1.7±0.68)分;对照组1患者上述指标分别为(14.3±2.00)次、(3.5±0.53)次、(3.5±0.85)次、(2.4±0.52)次、(9.9±0.99)分、(3.9±0.74)分,(10.3±2.05)次、(2.3±0.48)次、(2.1±0.88)次、(1.2±0.42)次、(4.9±1.29)分、(2.1±0.57)分;对照组2患者上述指标分别为(14.1±2.02)次、(3.5±0.97)次、(3.5±1.08)次、(2.6±0.52)次、(10.0±1.76)分、(3.6±0.84)分,(11.6±1.83)次、(2.6±0.70)次、(2.3±0.95)次、(1.7±0.48)次、(5.9±1.19)分、(2.6±0.84)分;3组患者治疗前后上述指标比较,差异均有统计学意义(t=20.146、8.573、9.798、8.510、17.667、7.571、26.833、9.192、8.571、9.833、16.842、10.554、11.180、5.014、4.649、7.090、9.462、4.610,均P<0.05)。试验组总有效率为83.3%(25/30),高于对照�Objective To study the effect of Modified Buzhong Yiqi Decoction and acupoint application in the treatment of patients with overactive bladders.Methods Ninety-one female patients with overactive bladders treated at Department of Urology,Guangdong Provincial Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to March 2024 were selected for the randomized controlled trial,and were divided into an experimental group(30 case),a control group 1(30 cases),and a control group 2(31 cases)by the random number table method.The experimental group were(46.72±10.13)years old,with a disease course of(3.09±2.49)years.The control group 1 were(46.98±11.29)years old,with a disease course of(3.18±2.63)years.The control group 2 were(47.48±10.11)years old,with a disease course of(3.08±2.44)years.The experimental group were treated by modified Buzhong Yiqi Decoction and acupoint application,the control group 1 with solifenacin succinate,and the control group 2 with modified Buzhong Yiqi Decoction,for 12 weeks.The urination diary(urination times during day time and night,urgency to urinate,and urge incontinence),scores of life quality,and overactive bladder syndrome scores(OABSS)before the treatment and after 12 weeks'treatment,clinical efficacies,and incidence rates of adverse reactions were compared between the 3 groups.t and χ^(2) tests were used for the statistical analysis.Results The urination times during day time and night and times of urgency to urinate and urge incontinence in 24 h,OABSS,and scores of life quality before the treatment and after 12 weeks'treatment in the experimental group were(14.4±1.57)times,(3.5±0.71)times,(3.5±0.53)times,(2.5±0.53)times,9.7±1.16,3.9±0.88,(10.1±1.10)times,(2.1±0.57)times,(1.9±0.57)times,(1.2±0.42)times,4.4±1.26,and 1.7±0.68;those in the control group 1 were(14.3±2.00)times,(3.5±0.53)times,(3.5±0.85)times,(2.4±0.52)times,9.9±0.99,3.9±0.74,(10.3±2.05)times,(2.3±0.48)times,(2.1±0.88)times,(1.2±0.42)times,4.9±1.29,and 2.1±0.57;those

关 键 词：膀胱过度活动症 补中益气汤加减 穴位敷贴 

分 类 号：R69[医药卫生—泌尿科学]