P(NIPAm-co-AA)水凝胶的制备与性能  

Preparation and properties of P(NIPAm-co-AA)hydrogel

作　　者：刘佳欣 高玉华[2] 徐智策[1] 李海花[2] 张苗苗 LIU Jiaxin;GAO Yuhua;XU Zhice;LI Haihua;ZHANG Miaomiao(School of Chemical and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China;Institute of Energy Resources,Hebei Academy of Sciences,Shijiazhuang 050081,China)

机构地区：[1]河北科技大学化学与制药工程学院,河北石家庄050018 [2]河北省科学院能源研究所,河北石家庄050081

出　　处：《应用化工》2024年第11期2589-2593,2599,共6页Applied Chemical Industry

基　　金：河北省重点研发计划项目(21371201D);河北省科学院科技计划项目(24702)。

摘　　要：以L-聚天冬氨酸为原料,通过热缩聚反应合成聚琥珀酰亚胺(PSI),PSI与乙醇反应,丙烯酰化后得到交联剂丙烯酰氧乙胺基聚琥珀酰亚胺(AEA-PSI)。以N-异丙基丙烯酰胺(NIPAm)和丙烯酸(AA)为单体,AEA-PSI为交联剂合成载药水凝胶P(NIPAm-co-AA)。研究了水凝胶的药物释药性能和生物降解性能。结果表明,当P(NIPAm-co-AA)水凝胶的NIPAm/AA摩尔配比为92/8,AEA-PSI用量为4%,温度为37℃时,药物的缓释效果最好,24 h内缓释率可达60%。胃蛋白酶的加入对药物的缓释率无明显影响。P(NIPAm-co-AA)水凝胶在模拟胃液中的降解率高于在模拟肠液中的降解率,24 h内,水凝胶在模拟胃液中的降解率均达到15%以上。Polysuccinimide(PSI)was synthesized from L-polyaspartic acid by thermal polycondensation reaction.The crosslinking agent acryloxyethylamine polysuccinimide(AEA-PSI)was obtained by the reaction of PSI with ethanol and acrylylation PSI reacted with ethanol.The P(NIPAm-co-AA)hydrogel was synthesized with N-isopropylacrylamide(NIPAm)and acrylic acid(AA)as monomers and AEA-PSI as crosslinkers.The drug sustained release and biodegradation properties of P(NIPAm-co-AA)hydrogel were studied.The results showed that when the NIPAm/AA molar ratio of P(NIPAm-co-AA)hydrogel was 92/8,the dosage of AEA-PSI was 4%,and the temperature was 37℃,the sustained release effect of P(NIPAm-co-AA)hydrogel was the best,and the sustained release rate reached 60%within 24 h.The addition of pepsin had no significant effect on the sustained release rate of the drug.The degradation rate of P(NIPAm-co-AA)hydrogel in simulated gastric fluid was higher than that in simulated intestinal fluid,and the degradation rate of P(NIPAm-co-AA)hydrogel in simulated gastric fluid reached more than 15%within 24 h.

关 键 词：水凝胶 N-异丙基丙烯酰胺 聚天冬氨酸 药物缓释 生物降解 

分 类 号：TQ317[化学工程—高聚物工业]