凝血四项和肿瘤标志物对肝脏疾病的临床诊断价值  

Clinical Values of Application of Coagulation Four Items and Tumor Markers in Liver Diseases

作　　者：司秀文[1] 赵海贝 李娜[1] SI Xiu-wen;ZHAO Hai-bei;LI Na(Department Laboratory Medicine,Binzhou Medical University Hospital,Binzhou,Shandong 256600,China)

机构地区：[1]滨州医学院附属医院检验科,山东滨州256600

出　　处：《河北北方学院学报(自然科学版)》2025年第2期10-14,共5页Journal of Hebei North University:Natural Science Edition

基　　金：国家自然科学基金青年基金(No.1802400)。

摘　　要：目的探讨凝血四项和肿瘤标志物检测在肝脏疾病中的临床诊断价值。方法选择150例肝脏疾病患者为观察组(其中肝癌组57例,肝硬化组59例,肝炎组34例),选取同期150例健康体检者为对照组,开展回顾性分析。检测凝血功能和肿瘤标志物水平,并进行诊断效能分析和指标与疾病程度的相关性分析。结果凝血四项:与对照组相比,观察组PT、APTT、TT均延长,FIB降低;肝硬化组中,APTT、PT、TT随着病情的进展逐渐增高,FIB逐渐下降。肿瘤标志物:与对照组相比,观察组中AFP、AFP-L3、CEA、CA19-9、CA125均升高;肝癌组中,随着疾病的进展,肿瘤标志物水平逐渐升高。根据受试者工作特征曲线可知,相较于单项检测,凝血四项和肿瘤标志物联合检测的曲线下面积最大。根据Pearson相关性分析可知,肝脏疾病严重程度与凝血四项和肿瘤标志物水平具有一定相关性。结论凝血四项和肿瘤标志物联合检测在诊断和预测肝脏疾病中具有重要的临床价值。Objective To analyze the clinical diagnostic value of the four coagulation items and tumor marker tests in liver diseases.Methods A total of 150 patients with liver diseases were selected as the observation group there were 57 cases in liver cancer group,59 cases in cirrhosis group and 34 cases in hepatitis group,and 150 healthy adults as the control group.The coagulation tests and tumor marker levels of patients in different groups were compared,and the analysis of the diagnostic efficacy and the correlation between the indexes and the degree of disease were performed.Results Coagulation tests:compared with the control group,PT,APTT and TT were prolonged in the observation group,and FIB was lower than that of the control group;in each group of cirrhosis,APTT,PT and TT showed a trend of gradual increase with the progress of disease severity,and FIB showed a gradual decrease trend.Tumor markers:compared with the control group,AFP,AFP-L3,CEA,CA199 and CA25 were elevated in the observation group;in each group of hepatocellular carcinoma,the levels of tumor markers showed a trend of gradual increase with the progression of disease.According to the analysis of the ROC,it can be seen that the area under the curve of the combined test of the four coagulation items and tumor markers had the largest AUC compared to the single test.According to the Pearson correlation analysis,the severity of liver disease was correlated to some extent with the levels of both coagulation quadruple and tumor markers.Conclusion The combined test of coagulation four and tumor markers has important clinical value in the diagnosis and prediction of liver diseases and is worth promoting.

关 键 词：凝血四项 肿瘤标志物 肝脏疾病 

分 类 号：R446.1[医药卫生—诊断学] R512.6[医药卫生—临床医学]