美托洛尔治疗老年高血压性心脏病室性心律失常的临床效果及对心功能的影响  

Effect of Metoprolol on Ventricular Arrhythmia and Cardiac Function in Elderly Patients with Hypertensive Heart Disease

作　　者：韩晓阳 王莎 HAN Xiao-yang;WANG Sha(Department of Cardiovascular Medicine,Yuxian People’s Hospital,Yuxian,Hebei 075700,China;Department of Nephrology,Yuxian People’s Hospital,Yuxian,Hebei 075700,China)

机构地区：[1]蔚县人民医院心血管内科,河北蔚县075700 [2]蔚县人民医院肾内科,河北蔚县075700

出　　处：《河北北方学院学报(自然科学版)》2025年第2期19-22,共4页Journal of Hebei North University:Natural Science Edition

摘　　要：目的探讨美托洛尔对高血压性心脏病室性心律失常老年患者的治疗效果及其对心功能的影响。方法采用随机数字表法将120例高血压性心脏病室性心律失常老年患者分为对照组与观察组各60例。对照组应用厄贝沙坦治疗,观察组在对照组治疗基础上加用美托洛尔。观察2组治疗总有效率及血压、心率、QT离散度、心脏功能等变化。结果观察组治疗总有效率显著高于对照组(P<0.05)。治疗前2组患者收缩压、舒张压和心率差异无统计学意义(P>0.05),治疗后均下降且观察组下降更显著(P<0.05)。治疗前2组患者QTc和QTd差异无统计学意义(P>0.05),治疗后患者QT离散度指标均降低且观察组降低更显著(P<0.05)。治疗前2组患者LVEF、LVESD和CO差异无统计学意义(P>0.05);治疗后患者LVEF和CO升高,LVESD降低,观察组改善优于对照组(P<0.05)。2组患者低血压等不良事件发生率差异无统计学意义(P>0.05)。结论美托洛尔可显著提高高血压性心脏病室性心律失常患者治疗总有效率,有效降低血压,恢复心率至正常范围,改善QT离散度,增强心功能,且不明显增加不良事件发生率。Objective To investigate the therapeutic effect of metoprolol on ventricular arrhythmia in elderly patients with hypertensive heart disease and its effect on cardiac function.Methods A total of 120 elderly patients with hypertensive heart disease ventricular arrhythmia were randomly divided into control group and observation group,with 60 cases in each group.The control group was treated with irbesartan,and the observation group with metoprolol on the basis of the control group.The total effective rate,blood pressure,heart rate,QT dispersion and cardiac function of the two groups were observed.Results The total effective rate of the observation group was significantly higher than that of the control group(P<0.05).After treatment,it decreased and the observation group decreased more significantly(P<0.05).There was no statistically significant difference in systolic blood pressure,diastolic blood pressure,and heart rate between the two groups of patients before treatment(P>0.05).After treatment,the QT dispersion index of the patients decreased and the observation group decreased more significantly(P<0.05).There was no statistically significant difference in QTc and QTd between the two groups of patients before treatment(P>0.05).After treatment,LVEF and CO increased,LVESD decreased,and the improvement in the observation group was better than that in the control group(P<0.05).There was no significant difference in the incidence of adverse events such as hypotension between the two groups(P>0.05).Conclusion Metoprolol can significantly improve the total effective rate of treatment in patients with hypertensive heart disease ventricular arrhythmia,effectively reduce blood pressure,restore heart rate to normal range,improve QT dispersion,enhance cardiac function,and do not significantly increase the incidence of adverse events.

关 键 词：老年 高血压性心脏病 室性心律失常 美托洛尔 心功能 

分 类 号：R541.3[医药卫生—心血管疾病] R541.7[医药卫生—内科学]