急性心肌梗死合并心力衰竭与IL-6、IL-8、IL-1β水平相关性分析  

Correlation Analysis of Acute Myocardial Infarction Complicated with Heart Failure and Levels of IL-6,IL-8,and IL-1β

作　　者：贾慧宇[1] 王书旺 李海红 董越 JIA Hui-yu;WANG Shu-wang;LI Hai-hong;DONG Yue(Clinical Laboratory,The Second Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei 075100,China;Zhangjiakou Xuangang Hospital,Zhangjiakou,Hebei 075000,China;Department of Cardiology,Chongli Hospital,The Third Hospital of Peking University,Zhangjiakou,Hebei 076350,China)

机构地区：[1]河北北方学院附属第二医院检验科,河北张家口075100 [2]张家口宣钢医院,河北张家口075000 [3]北京大学第三医院崇礼院区心内科,河北张家口076350

出　　处：《河北北方学院学报(自然科学版)》2025年第2期28-30,共3页Journal of Hebei North University:Natural Science Edition

摘　　要：目的探讨急性心肌梗死(acute myocardial infarction,AMI)患者细胞因子IL-6、IL-8、IL-1β水平变化的临床意义。方法选取30例急性心肌梗死合并心力衰竭患者为观察组,同期30例急性心肌梗死非心力衰竭患者为对照组。采用多重微球流式免疫荧光发光法检测IL-6、IL-8、IL-1β水平;酶联免疫法检测NT-proBNP水平。使用彩色多普勒超声显像仪检测左室射血分数(left ventricular ejection fraction,LVEF)、左室收缩末期容积(left ventricular end-systolic volume,LVESV)及左室舒张末期容积(left ventricular end-diastolic volume,LVEDV)。结果观察组患者血浆IL-6、NT-proBNP水平高于对照组(P<0.05);IL-8、IL-1β水平组间比较差异无统计学意义(P>0.05);LVEF低于对照组(P<0.05);LVESV、LVEDV组间比较差异无统计学意义(P>0.05)。Spearman相关分析显示,2组患者IL-6水平与LVEF呈负相关(r=-0.241,P<0.05),与NT-proBNP水平呈正相关(r=0.310,P<0.05);IL-8、IL-1β与NT-proBNP、LVEF及IL-6、IL-8、IL-1β与LVESV、LVEDV间无明显相关(P>0.05)。结论炎症反应在AMI后病情进展中起重要作用,IL-6可能参与了AMI后心力衰竭的发展,调整细胞因子水平可能成为治疗AMI后心衰新思路。Objective To investigate the clinical significance of changes of IL-6,IL-8 and IL-1 levels in patients with acute myocardial infarction(AMI).Methods A total of 30 patients with acute myocardial infarction complicated with heart failure were selected as the observation group,and 30 patients with acute myocardial infarction without heart failure as the control group.The levels of IL-6,IL-8 and IL-1βwere detected by multiple microsphere flow immunofluorescence luminescence method.The level of NT-proBNP was detected by enzyme-linked immunosorbent assay.Left ventricular ejection fraction(LVEF),left ventricular end-systolic volume(LVESV)and left ventricular end-diastolic volume(LVEDV)were measured by color Doppler ultrasound.Results The levels of plasma IL-6 and NT-proBNP in the observation group were higher than those in the control group(P<0.05).LVEF was lower than that of the control group(P<0.05).Spearman correlation analysis showed that IL-6 level was negatively correlated to LVEF(r=-0.241,P<0.05)and positively correlated to NT-proBNP level(r=0.310,P<0.05).There was no significant correlation between IL-8,IL-1βand NT-proBNP,LVEF,IL-6,IL-8,IL-1βand LVESV,LVEDV(P>0.05).Conclusion Inflammatory response plays an important role in the progression of AMI.IL-6 may be involved in the development of heart failure after AMI.Regulating the level of cytokines may become a new idea for the treatment of heart failure after AMI.

关 键 词：急性心肌梗死 NT-PROBNP IL-6 心功能 

分 类 号：R542.22[医药卫生—心血管疾病]