宫颈息肉相关高危因素分析  

Analysis of high-risk factors associated with the development of cervical polyps

作　　者：赵超 余璐 刘迎 党丽娟 杨林青[2] Zhao Chao;Yu Lu;Liu Ying;Dang Lijuan;Yang Linqing(Department of Clinical Medicine,Jining Medical College,Jining 272067,China;Department of Obstetrics and Gynecology,Affiliated Hospital of Jining Medical College,Jining 272069,China)

机构地区：[1]济宁医学院临床医学院,济宁272067 [2]济宁医学院附属医院妇产科,济宁272069

出　　处：《国际医药卫生导报》2025年第1期89-93,共5页International Medicine and Health Guidance News

基　　金：山东省医药卫生科技项目(202305010415);济宁医学院附属医院“苗圃”科研计划(MP-ZD-2023-05)。

摘　　要：目的探讨宫颈息肉的相关临床高危因素,建立预测模型以提高人群对该疾病的警惕。方法本研究为回顾性研究。选取2021年12月1日至2022年12月1日于济宁医学院附属医院行宫腔镜手术的239例患者作为研究对象,根据术后病理结果将患者分为宫颈息肉组和非宫颈息肉组。宫颈息肉组患者131例,年龄27~77岁,中位年龄49岁;非宫颈息肉组患者108例,年龄15~58岁,中位年龄44岁。采用单因素分析以及多因素二元logistic回归分析宫颈息肉发生的危险因素,采用受试者操作特征曲线(ROC)检验相关高危因素对宫颈息肉发生风险的评估价值。统计学方法采用Mann-Whitney U检验、χ^(2)检验或Fisher确切概率法。结果单因素分析结果显示,宫颈息肉组与非宫颈息肉组的年龄、体重指数、肥胖(体重指数≥25 kg/m^(2))、孕次、产次以及绝经、高血压[收缩压≥140 mmHg(1 mmHg=0.133 kPa)和(或)舒张压≥90 mmHg]、子宫肌瘤、子宫内膜息肉发生率比较,差异均有统计学意义(均P<0.05)。多因素二元logistic回归分析结果显示,肥胖[比值比(OR)=5.080,95%置信区间(95%CI)1.769~14.588,P=0.003]、高血压(OR=6.629,95%CI 2.456~17.890,P<0.001)、子宫肌瘤(OR=2.018,95%CI 1.020~3.993,P=0.044)、子宫内膜息肉(OR=3.623,95%CI 1.806~7.265,P<0.001)和孕次(OR=1.349,95%CI 1.037~1.755,P=0.026)均是宫颈息肉的临床危险因素。ROC分析结果显示,肥胖、高血压、子宫肌瘤、子宫内膜息肉、孕次单一因素检测宫颈息肉发病的诊断价值均较低[均曲线下面积(AUC)<0.7];上述指标联合检测AUC=0.808(95%CI 0.753~0.864),联合检测对宫颈息肉发病的诊断价值为中等(AUC>70)。结论肥胖、高血压、子宫肌瘤、子宫内膜息肉、孕次均是宫颈息肉发病的高危因素,上述指标联合检测的诊断价值高于单一指标检测,便于临床医生早期筛选高危人群。Objective To investigate the clinical risk factors associated with the development of cervical polyps and to develop a predictive model to increase population vigilance on this disease.Methods This was a retrospective study.A total of 239 patients who underwent hysteroscopic surgery in the Department of Gynecology,Affiliated Hospital of Jining Medical College from December 1,2021 to December 1,2022 were selected as the study objects,and were divided into two groups according to postoperative pathological data.Among them,131 patients with cervical polyps ranged in age from 27 to 77 years old,with a median age of 49 years old;108 patients without cervical polyps ranged in age from 15 to 58 years old,with a median age of 44 years old.Univariate analysis and multivariate binary logistic regression analysis were used to analyze the risk factors of cervical polyps,and the receiver operating characteristic curve(ROC)was used to test the evaluation value of relevant risk factors of cervical polyps.Mann-Whitney U test,χ^(2) test,or Fisher exact probability method were used for statistical analysis.Results The results of univariate analysis showed that there was statistically significant differences in the incidence of age,body mass index(BMI),obesity(BMI≥25 kg/m^(2)),gestational time,menopause,hypertension[systolic blood pressure≥140 mmHg(1 mmHg=0.133 kPa)and/or diastolic blood pressure≥90 mmHg],uterine fibroids,or endometrial polyps between the cervical polyp group and the non-cervical polyp group(all P<0.05).Multivariate binary logistic regression analysis showed that obesity[odds ratio(OR)=5.080,95%confidence interval(95%CI)1.769-14.588,P=0.003],hypertension(OR=6.629,95%CI 2.456-17.890,P<0.001),uterine fibroids(OR=2.018,95%CI 1.020-3.993,P=0.044),endometrial polyps(OR=3.623,95%CI 1.806-7.265,P<0.001),and pregnancy times(OR=1.349,95%CI 1.037-1.755,P=0.026)were clinical risk factors for cervical polyps.ROC analysis results showed that the combined detection of obesity,hypertension,uterine fibroids,endometrial poly

关 键 词：宫颈息肉 危险因素 临床调查 受试者操作特征曲线 

分 类 号：R73[医药卫生—肿瘤]