乳腺癌抗肿瘤药物心脏毒性的研究进展及中医药干预  

Research Progress on Cardiotoxicity of Anti-cancer Drugs for Breast Cancer and Traditional Chinese Medicine Intervention

作　　者：高阳 宋晓耘[1] 刘胜[1,2] 周细秋 孙霃平[3] 史有阳[1] GAO Yang;SONG Xiaoyun;LIU Sheng;ZHOU Xiqiu;SUN Chenping;SHI Youyang(Department of Breast Surgery,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Graduate School of Shanghai University of Traditional Chinese Medicine,Shanghai 200210,China;Breast Surgery Department of Integrated Traditional Chinese and Western Medicine,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院乳腺外科,上海200032 [2]上海中医药大学研究生院,上海200120 [3]上海中医药大学附属龙华医院中西医结合乳腺科,上海200032

出　　处：《世界中医药》2024年第19期3045-3051,共7页World Chinese Medicine

基　　金：国家自然科学基金青年科学基金项目(81603629,82205114);上海市科技创新行动计划面上项目(23ZR1464100)。

摘　　要：心脏毒性是抗肿瘤药物最主要的不良反应之一,乳腺癌抗肿瘤药物中蒽环类、烷化剂类、抗代谢药物、紫杉烷类药物、分子靶向药物、芳香化酶抑制剂等均具有心脏毒性。中医药对乳腺癌抗肿瘤药物有增效减毒的作用。本文通过对引起心脏毒性的乳腺癌抗肿瘤药物的机制进行综述,总结分析近五年中医药降低乳腺癌抗肿瘤药物心脏毒性的最新临床和实验研究,为中医药降低乳腺癌抗肿瘤药物心脏毒性的机制阐述、新药开发以及临床治疗提供借鉴。Cardiotoxicity is one of the most significant adverse effects of anti-cancer drugs.Among the drugs used for breast cancer treatment,anthracyclines,alkylating agents,antimetabolites,taxanes,molecular targeted drugs,and aromatase inhibitors all have cardiotoxic effects.Traditional Chinese medicine(TCM)plays a role in enhancing the efficacy and reducing the toxicity of breast cancer chemotherapy.This article reviews the mechanisms of cardiotoxicity caused by breast cancer anti-cancer drugs,summarizes and analyzes the latest clinical and experimental research over the past five years on TCM′s role in reducing cardiotoxicity of these drugs,thereby aiming to provide insights for elucidating the mechanisms by which TCM mitigates the cardiotoxicity of breast cancer anti-cancer drugs,as well as for the development of new drugs and clinical treatment strategies.

关 键 词：中医药 乳腺癌 抗肿瘤药物 心脏毒性 作用机制 临床研究 基础研究 研究进展 

分 类 号：R273[医药卫生—中西医结合] R284[医药卫生—中医肿瘤科]