疏肝解郁安神方联合艾司唑仑治疗肝郁化火型慢性失眠临床研究  

Clinical Study on Shugan Jieyu Anshen Prescription Combined with Estazolam for Chronic Insomnia of Liver Constraint Transforming into Fire Type

作　　者：林秀慧 缪一艇 王逸如 吴旭杰 赵娜[1] LIN Xiuhui;MIU Yiting;WANG Yiru;WU Xujie;ZHAO Na(Department of Neurology,Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University,Wenzhou Zhejiang 325000,China)

机构地区：[1]浙江中医药大学附属温州市中医院神经内科,浙江温州325000

出　　处：《新中医》2025年第1期42-46,共5页New Chinese Medicine

摘　　要：目的:观察疏肝解郁安神方联合艾司唑仑治疗肝郁化火型慢性失眠的临床疗效及对神经递质的影响。方法:采用随机数字表法将2024年1—4月浙江中医药大学附属温州市中医院收治的106例肝郁化火型慢性失眠患者分为试验组和对照组各53例。对照组接受艾司唑仑治疗,试验组在对照组基础上给予疏肝解郁安神方治疗,2组疗程均为4周。比较2组治疗前后中医证候积分、匹兹堡睡眠质量指数(PSQI)、抑郁自评量表(SDS)、焦虑自评量表(SAS)及神经递质水平,比较2组临床疗效及不良反应发生率。结果:治疗后,试验组总有效率94.34%(50/53),高于对照组81.13%(43/53)(P<0.05)。治疗后,2组中医证候积分、PSQI评分、SAS评分、SDS评分及多巴胺(DA)水平均较治疗前降低(P<0.05),5-羟色胺(5-HT)、γ-氨基丁酸(GABA)水平升高(P<0.05),且试验组中医证候积分、PSQI评分、SAS评分、SDS评分及DA水平低于对照组(P<0.05),5-HT、GABA水平高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:疏肝解郁安神方联合艾司唑仑治疗肝郁化火型慢性失眠效果良好,能够有效提升患者睡眠质量,改善焦虑、抑郁情绪,调节神经递质水平,安全性较高。Objective:To observe the clinical effect of Shugan Jieyu Anshen Prescription combined with Estazolam for chronic insomnia of the liver constraint transforming into fire type and its impact on neurotransmitters.Methods:A total of 106 patients with chronic insomnia of the liver constraint transforming into fire type admitted to Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University from January to April 2024 were divided into the trial group and the control group according to the random number table method,with 53 cases in each group.The control group received treatment with Estazolam,and the trial group was treated with Shugan Jieyu Anshen Prescription based on the treatment of the control group.Both groups had a treatment course of four weeks.Traditional Chinese medicine(TCM)syndrome scores,Pittsburgh Sleep Quality Index(PSQI)scores,Self-Rating Depression Scale(SDS)scores,Self-Rating Anxiety Scale(SAS)scores,and levels of neurotransmitters were compared before and after treatment between the two groups;the clinical effects and incidence of adverse reactions were compared between the two groups.Results:After treatment,the total effective rate in the trial group was 94.34%(50/53),which was higher than that of 81.13%(43/53)in the control group(P<0.05).After treatment,TCM syndrome scores,the scores of PSQI,SAS,and SDS,and dopamine(DA)levels in the two groups were reduced when compared with those before treatment(P<0.05),and the levels of 5-hydroxytryptamine(5-HT)and gammaaminobutyric acid(GABA)were increased(P<0.05);TCM syndrome scores,the scores of PSQI,SAS,and SDS,and DA level in the trial group were lower than those in the control group(P<0.05),and the levels of 5-HT and GABA were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of Shugan Jieyu Anshen Prescription and Estazolam has a good effect on the treatment of chronic insomnia with the syndrome of the

关 键 词：慢性失眠 肝郁化火 疏肝解郁安神方 艾司唑仑 睡眠质量 神经递质 

分 类 号：R256.23[医药卫生—中医内科学]