温经活血汤联合布洛芬治疗原发性痛经临床研究  

Clinical Study on Wenjing Huoxue Decoction Combined with Ibnprofen for Primary Dysmenorrhea

作　　者：杨冬冬 龚杏姿 章婷 苏莎莎 YANG Dongdong;GONG Xingzi;ZHANG Ting;SU Shasha(Graduate School of Zhejiang Chinese Medical University,Hangzhou Zhejiang 310053,China;Department of Gynecology,Cangnan Hospital of Traditional Chinese Medicine,Cangnan Zhejiang 325800,China)

机构地区：[1]浙江中医药大学研究生院,浙江杭州310053 [2]苍南县中医院妇科,浙江苍南325800

出　　处：《新中医》2025年第1期82-85,共4页New Chinese Medicine

摘　　要：目的:观察温经活血汤联合布洛芬治疗原发性痛经的效果及对前列腺素F2α(PGF2α)、内皮素-1(ET-1)的影响。方法:选取2021年3月—2023年3月苍南县中医院收治的80例原发性痛经患者作为研究对象,按随机数字表法分为中医组和西医组各40例。西医组给予布洛芬治疗,中医组在西医组的基础上给予温经活血汤治疗,2组均持续治疗6个月经周期。评价2组临床疗效,比较2组治疗前后中医证候评分、PGF2α、ET-1水平及生活质量评分,统计不良反应发生情况。结果:2组总有效率比较,差异无统计学意义(P>0.05);中医组愈显率高于西医组(P<0.05)。治疗后,2组各项中医证候评分较治疗前降低(P<0.05),且中医组各项中医证候评分低于西医组(P<0.05)。治疗后,2组PGF2α、ET-1水平较治疗前降低(P<0.05),且中医组PGF2α、ET-1水平低于西医组(P<0.05)。治疗后,2组生存质量量表(WHOQOLBREF)各维度评分较治疗前升高(P<0.05),且中医组WHOQOL-BRFF量表各维度评分高于西医组(P<0.05)。2组均未出现恶心、呕吐、皮疹、头晕等不良反应。结论:温经活血汤联合布洛芬能够有效缓解原发性痛经患者的临床症状,降低患者疼痛程度,从而提高患者生活质量。Objective:To observe the effects of Wenjing Huoxue Decoction combined with Ibnprofen on primary dysmenorrhea and its impact on prostaglandin F2α(PGF2α)and endothelin-1(ET-1).Methods:A total of 80 cases of patients with primary dysmenorrhea treated at Cangnan Hospital of Traditional Chinese Medicine from March 2021 to March 2023 were selected and divided into the Chinese medicine group and the western medicine group according to the random number table method,with 40 cases in each group.The western medicine group was given Ibnprofen,and the Chinese medicine group was additionally treated with Wenjing Huoxue Decoction based on the treatment given to the western medicine group.Both groups were treated for six menstrual cycles.Clinical effects in the two groups were evaluated;traditional Chinese medicine syndrome scores,levels of PGF2αand ET-1,and quality of life scores in the two groups were compared before and after treatment;adverse reactions were recorded.Results:There was no significant difference being found in the comparison of the total effective rates between the two groups(P>0.05);the curative obvious rate in the Chinese medicine group was higher than that in the western medicine group(P<0.05).After treatment,the traditional Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),with the Chinese medicine group scoring lower than the western medicine group(P<0.05).After treatment,levels of PGF2αand ET-1 in the two groups were reduced when compared with those before treatment(P<0.05),with the Chinese medicine group showing lower levels than the western medicine group(P<0.05).After treatment,the scores of World Health Organization Quality of Life-BREF(WHOQOL-BREF)in the two groups were improved when compared with those before treatment(P<0.05),with the Chinese medicine group scoring higher than the western medicine group(P<0.05).No adverse reactions such as nausea,vomiting,rash,or dizziness were observed in either group.Conclusion:Wenjing Huoxue

关 键 词：原发性痛经 寒凝血瘀型 温经活血汤 前列腺素F2Α 内皮素-1 生活质量 

分 类 号：R711.51[医药卫生—妇产科学]