卵巢漿液性癌患者HLA-G的表達與預後  

Expression and prognosis of human leukocyte antigen G in ovarian serous carcinoma

作　　者：孫麗麗 關峰 張帆 陳藝華 SUN Li Li;GUAN Feng;ZHANG Fan;CHEN Yi Hua(Reproductive Medicine Center,Affiliated Zhongshan Hospital of Dalian University,Dalian,China;Gynaecology department,Affiliated Zhongshan Hospital of Dalian University,Dalian,China)

机构地区：[1]大連大學附屬中山醫院生殖醫學中心 [2]大連大學附屬中山醫院婦科

出　　处：《镜湖医学》2024年第2期17-20,54,F0003,共6页MEDICAL JOURNAL OF KIANG WU

摘　　要：目的探討人類白細胞抗原G(humanleukocyte antigen,HLA-G)在卵巢漿液性癌(serous ovarian carcinoma,SOC)組織中的表達與患者預後的關係。方法回顧性分析SOC患者臨床及病理資料,免疫組化法檢測SOC組織中HLA-G表達情況,並分析其與臨床病理特徵及預後的關係。結果HLA-G蛋白陽性率在SOC癌組織(77.08%)中顯著高於癌旁組織(6.25%)。94.44%的HLA-G低表達組卵巢癌患者臨床病理分期是III-IV期,與HLA-G高表達組患者臨床病理分期比較,有統計學差異。HLA-G低表達組平均生存時間62.77±7.82月,HLA-G高表達組平均生存時間92.13±15.2月。Kaplan-Meier生存分析顯示HLA-G高表達組5年的生存率為75%,高於HLA-G低表達組的5年生存率52%,但無統計學差異。Cox回歸分析顯示,化療耐藥(HR=10.700,95%CI=3.433~33.349,P=0.000)是SOC患者不良預後的預測因子,而HLA-G高表達(HR=0.132,95%CI=0.035~1.098,P=0.045)是保護性因素。結論與正常組織相比HLA-G在SOC中表達較高。HLA-G在晚期SOC組織中比早期者表達量低,但其表達量與病理分級無關。HLA-G低表達的SOC患者預後更差,這可能與化療耐藥有關。Objective To investigate the relationship between human leukocyte antigen(HLA)-G expression and prognosis in serous ovarian carcinoma(SOC)patients.Methods The clinical and pathological data of SOC patients were retrospectively analyzed,and the expression of HLA-G in SOC tissues was detected by immunohistochemistry,and its relationship with clinicopathological features and prognosis was analyzed.Results HLA-G was positive in 77.08%(37/48)SOC tissues.In 94.44%HLA-G low-expression group,the clinicopathologic stage was advanced stage(III-IV),which was sinificantly different from that in the high-expression group.Howerver,there was no difference in pathological grade between the two groups.The average survival time of patients in the low-HLA-G expression group was 62.77±7.82 months,and that of patients in the high HLA-G expression group was 92.13±15.2 months.The Kaplan-Meier survival analysis revealed that the 5-year survival rate of the high-HLA-G expression group was 75%,which was higher than that of the low-expression HLA-G group of 52%,but the difference was not statistically significant.Cox regression analysis revealed that chemotherapy resistance was a predictor of adverse OS in SOC patients(HR=10.700,95%CI=3.433~33.349,P=0.000),whereas high expression of HLA-G was a protective factor(HR=0.132,95%CI=0.035~1.098,P=0.045).Conclusion HLA-G is highly expressed in SOC compared with normal tissues.The expression of HLA-G was low in advanced(stage III-IV)SOC patients,but was not related to the pathological grade.The SOC patients with low HLA-G expression have a worse prognosis,which may be related to chemotherapy resistance.

关 键 词：人類白細胞抗原G 卵巢漿液性癌SOC 化療耐藥 總生存期 預後 

分 类 号：R71[医药卫生—妇产科学]