基于海藻酸钠水凝胶敷料的制备及其性能研究  

Preparation and Performance of Hydrogel Dressing Based on Sodium Alginate

作　　者：战瑛洁 薛巍[1,2,3] 冯笑 ZHAN Yingjie;XUE Wei;FENG Xiao(Department of Biomedical Engineering,Jinan University,Guangzhou 510632,China;Key Laboratory of Biomaterials of Guangdong Higher Education Institutes,Guangzhou 510632,China;Engineering Technology Research Center of Drug Carrier of Guangdong,Guangzhou 510632,China;Longtime Biopharmaceutical Co.,Ltd.,Foshan 528225,China)

机构地区：[1]暨南大学生物医学工程系,广东广州510632 [2]广东省高等院校生物材料重点实验室,广东广州510632 [3]广东省药物载体工程技术研究中心,广东广州510632 [4]朗肽生物制药股份有限公司,广东佛山528225

出　　处：《纤维素科学与技术》2024年第4期13-18,共6页Journal of Cellulose Science and Technology

摘　　要：以海藻酸钠(SA)作为三维交联网络骨架,引入聚乙烯醇(PVA)和四臂聚乙二醇-环氧丙烷(4arm-PEG-EPO)后,同时显著增强水凝胶的内部交联密度和力学性能。制备SA-NP-PVA-PEG复合水凝胶具有稳定的交联网络结构,并对材料的红外谱图、微观形貌、力学性能以及粘附性能进行测试。结果表明:1.0%的PVA与1%的4arm-PEG-EPO通过氢键作用协同增效,交联结构分布均匀且孔径缩小至50~80μm;此外,少量交联剂还有助于增强粘附性能。综上所述,SA-NP-PVA-PEG具有低成本、良好生物相容性、优异的力学性能和粘附性能等优点,为发展新型水凝胶伤口敷料提供了新思路。SA is used as the three-dimensional cross-linking network framework,and the internal cross-linking density and mechanical properties of the hydrogel are significantly enhanced by the introduction of PVA and 4arm-PEG-EPO.The SA-NP-PVA-PEG composite hydrogel is prepared with a stable cross-linked network structure,and the physicochemical properties,micromorphology,and other properties of the materials are tested.The results show that 1.0%PVA and 1%4ARM-PEG-EPO are synergistically combined by hydrogen bonding,the cross-linked structure is evenly distributed and the pore size is reduced to 50~80μm.In addition,a small amount of crosslinker can help to enhance adhesion properties.In conclusion,SA-NP-PVA-PEG has the advantages of low cost,good biocompatibility,excellent mechanical properties and adhesion properties,which provides a new idea for the development of new hydrogel wound dressings.

关 键 词：水凝胶敷料 海藻酸钠 聚乙烯醇 交联网络结构 氢键作用 

分 类 号：O636.11[理学—高分子化学]