MetaDTA:一款诊断试验准确性Meta分析在线应用程序  

MetaDTA:an Online Application for Diagnostic Test Accuracy Meta-analysis

作　　者：杨水华 姚桂英[4] 田晨 晏毅龙 刘嘉艺 王佳佳 田金徽 牛猛[7] 葛龙 YANG Shuihua;YAO Guiying;TIAN Chen;YAN Yilong;LIU Jiayi;WANG Jiajia;TIAN Jinhui;NIU Meng;GE Long(Department of Social Science and Health Management,School of Public Health,Lanzhou University,Lanzhou 730000,China;Key Laboratory of Evidence Based Medicine of Gansu Province,Lanzhou 730000,China;Evidence-based Social Science Research Center,School of Public Health,Lanzhou University,Lanzhou 730000,China;Jinan Maternal and Child Health Centre,Jinan 250000,China;First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Evidence-based Medicine Center,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China;Department of Radiology,the First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学公共卫生学院卫生政策与管理学系,甘肃省兰州市730000 [2]甘肃省循证医学重点实验室,甘肃省兰州市730000 [3]兰州大学循证社会科学研究中心,甘肃省兰州市730000 [4]山东省济南市妇幼保健院,250000 [5]兰州大学第一临床医学院,甘肃省兰州市730000 [6]兰州大学基础医学院循证医学中心,甘肃省兰州市730000 [7]兰州大学第一医院放射科,甘肃省兰州市730000

出　　处：《中国全科医学》2025年第8期1023-1032,共10页Chinese General Practice

基　　金：国家自然科学基金资助项目(82204931);甘肃省教育厅创新基金(2022B-023);兰州大学第一医院基金(ldyyyn2021-73)。

摘　　要：MetaDTA是一款对诊断试验准确性研究进行Meta分析的在线、交互式应用程序,该应用程序调用R软件中lme4和shiny程序包实现统计分析并建立交互式用户界面。该应用程序无需用户了解任何有关统计和编程的知识,也无需安装任何专业软件,便于无专业统计知识的用户使用。本文将重点介绍MetaDTA平台诊断试验准确性的量化、结果可视化、交互式功能等,结合实例向用户介绍该应用程序的具体操作方法,旨在帮助相关研究人员完成诊断准确性研究Meta分析、绘制汇总受试者工作特征(SROC)曲线、绘制纳入研究质量评价结果以及进行敏感性分析。MetaDTA is an online,interactive application for Meta-analysis of diagnostic test accuracy studies,which calls on the lme4 and shiny packages in R software to perform the statistical analyses and create an interactive user interface.The application does not require any knowledge of statistics and programming,nor does it require any specialized software to be installed,making it easy to use for users with no specialized statistical knowledge.In this paper,we will focus on the quantification of diagnostic test accuracy,visualisation of results and interactive functions of the MetaDTA platform,and introduce users to the specific operation of the application with examples,aiming to help relevant researchers to complete Meta-analysis of diagnostic accuracy studies,plot summary receiver operating characteristic(SROC)curves,draw the results of the evaluation of the quality of the included studies,and carry out sensitivity analysis.

关 键 词：MetaDTA 诊断试验准确性研究 META分析 双变量模型 

分 类 号：R44[医药卫生—诊断学]