蓖麻油对阿霉素诱导扩张型心肌病心力衰竭大鼠心肌电生理作用  

Electrophysiological Effects of Castor Oil on Adriamycin Induced Dilated Cardiomyopathy in Rats with Heart Failure

作　　者：杨松骜 金禹辰 杜建军 贺智慧[3] 徐昊阳 田迅[1] YANG Songao;JIN Yuchen;DU Jianjun;HE Zhihui;XU Haoyang;TIAN Xun(College of Life Sciences and Food Engineering,Inner Mongolia Minzu University,Tongliao 028043,China;Tongliao People’s Hospital,Tongliao 028000,China;College of Basic Medicine,Inner Mongolia Minzu University,Tongliao 028043,China;Affiliated Hospital,Inner Mongolia Minzu University,Tongliao 028000,China)

机构地区：[1]内蒙古民族大学生命科学与食品学院,内蒙古通辽028043 [2]通辽市人民医院,内蒙古通辽028000 [3]内蒙古民族大学基础医学院,内蒙古通辽028043 [4]内蒙古民族大学附属医院,内蒙古通辽028000

出　　处：《内蒙古民族大学学报(自然科学版)》2025年第1期53-57,共5页Journal of Inner Mongolia Minzu University:Natural Sciences Edition

基　　金：内蒙古自治区开放基金计划项目(MDK202203)。

摘　　要：为明确蓖麻油对心力衰竭合并便秘患者的心脏安全性,采用动物实验的方法将大鼠分为正常对照组和阿霉素诱导扩张型心肌病组,利用多通道电标测技术记录分析二甲亚砜(DMSO)及DMSO+蓖麻油对正常大鼠及阿霉素诱导扩张型心肌病大鼠离体灌流心脏心电图(ECG)、左心室传导速度及传导离散度作用。结果显示,蓖麻油对正常大鼠及阿霉素诱导扩张型心肌病大鼠心电图(ECG)、左心室传导速度及传导离散度均无明显影响。因此,蓖麻油未引发正常大鼠及阿霉素诱导扩张型心肌病大鼠发生心律失常,心力衰竭合并便秘患者使用蓖麻油通便安全有效。In order to determine the cardiac safety of castor oil in patients with heart failure combined with constipation,rats were divided into a normal control group and an adriamycin-induced dilated cardiomyopathy group by using animal experiments,the effects of dimethylsulfoxide(DMSO)and DMSO+castor oil on electrocardiogram(ECG),left ventricular conduction velocity and conduction dispersion degree of isolated perfused hearts of normal rats and adriamycin-induced dilated cardiomyopathy rats were recorded and analyzed by multi-channel electrical mapping technique.The results showed that castor oil had no significant effect on electrocardiogram(ECG),left ventricular conduction velocity and conduction dispersion in normal rats and adriamycin-induced dilated cardiomyopathy rats.Therefore,castor oil did not trigger arrhythmia in normal rats and adriamycin-induced dilated cardiomyopathy rats,and the use of castor oil in patients with heart failure combined with constipation was safe and effective.

关 键 词：DMSO 蓖麻油 扩张型心肌病 多通道电标测系统 心律失常 

分 类 号：R542.2[医药卫生—心血管疾病]