基于数据挖掘探讨名老中医李中玉治疗肉芽肿性乳腺炎的用药规律  

Study on the Prescription Regularity of LI Zhong-yu,a Famous TCM Doctor,in the Treatment of Granulomatous Mastitis Based on Data Mining

作　　者：李跃文 李政 栗粟 姚登峰 安丽景 李中玉 LI Yue-wen;LI Zheng;LI Su;YAO Deng-feng;AN Li-Jing;LI Zhong-yu(Henan Province Hospital of TCM(the Second Affiliated Hospital of Henan University of Chinese Medicine),Zhengzhou 450002,China;Zhengzhou TCM Hospital,Zhengzhou 450007,China)

机构地区：[1]河南省中医院(河南中医药大学第二附属医院),郑州450002 [2]郑州市中医院,郑州450007

出　　处：《中国合理用药探索》2024年第12期9-14,共6页Chinese Journal of Rational Drug Use

基　　金：国家中医临床研究基地科研专项(2021JDZX2113)。

摘　　要：目的:基于真实临床研究,分析名老中医李中玉治疗肉芽肿性乳腺炎(GM)的中药组方规律,为中医药治疗GM提供切实有效的方案。方法:收集2021年1月1日~2022年12月31日名老中医李中玉治疗GM的中药处方,采用Excel表格对涉及中药的使用频率、性味归经等进行统计分析,采用Cytoscape3.7.2软件筛选治疗GM的核心中药,采用IBM SPSS Modeler 18.0软件和IBM SPSS Statistics 23.0软件对核心中药分别进行关联规则分析和系统聚类分析。结果:共收集整理565个处方,涉及55味中药,累计使用5318次,多为补虚药、清热药、解表药、活血化瘀药等,以性寒、温、平,味甘、苦、辛,入肝、胃经为主。经拓扑学筛选得到当归、黄芪、蒲公英、金银花、白芷等14味核心中药,关联规则分析显示黄芪-当归、蒲公英-当归、蒲公英-黄芪-当归,金银花-黄芪-当归等组合的频数和支持度均较高,系统聚类分析得到3类潜在配伍关系组合。结论:名老中医李中玉治疗GM多以补虚药、清热药、解表药、活血化瘀药等为主,临床多应用当归、黄芪、蒲公英、金银花、白芷等核心中药组成的经典方剂。Objective:To analyze the traditional Chinese medicine(TCM)prescription regularity of LI Zhong-yu,a famous TCM doctor,in the treatment of granulomatous mastitis(GM)based on real-world clinical studies,providing a practical and effective scheme for the treatment of GM with TCM.Methods:The TCM prescriptions of LI Zhong-yu in the treatment of GM from January 1,2021 to December 31,2022 were collected.The medication frequency,property and flavor,and meridian tropism of the TCMs were statistically analyzed using Excel.The core TCMs for treating GM were screened by Cytoscape3.7.2 software.The association rule analysis and hierarchical clustering analysis were performed for the core TCMs by IBM SPSS Modeler 18.0 software and IBM SPSS Statistics 23.0 software,respectively.Results:A total of 565 prescriptions were collected and sorted out,involving 55 different TCMs,with a total of 5318 times of use.Most of them were used for tonifying deficiency,clearing heat,relieving exterior symptoms,and activating blood circulation and removing blood stasis,etc.These TCMs were characterized by cold,warm or neutral properties,with sweet,bitter or pungent tastes,primarily targeting the liver and stomach meridians.Through topological analysis,14 core TCMs were screened and identified,such as Angelicae sinensis radix,Astragali radix,Taraxaci herba,Lonicerae japonicae flos,and Angelicae dahuricae radix.The association rule analysis showed that combinations of Astragali radix-Angelicae sinensis radix,Taraxaci herba-Angelicae sinensis radix,Taraxaci herba-Astragali radix-Angelicae sinensis radix,Lonicerae japonicae flos-Astragali radix-Angelicae sinensis radix had higher frequencies and support levels.The hierarchical clustering analysis identified three potential combinatory relationships.Conclusion:LI Zhong-yu,a famous TCM doctor,primarily prescribed TCMs of tonifying deficiency,clearing heat,relieving exterior symptoms,and activating blood circulation and removing blood stasis,etc.,in the treatment of GM.In clinical practice,classic prescr

关 键 词：肉芽肿性乳腺炎 数据挖掘 组方规律 关联规则分析 系统聚类分析 

分 类 号：R269[医药卫生—中西医结合]