来曲唑联合尿促性素促排卵方案与人工周期方案在多囊卵巢综合征不孕患者行冻融单囊胚移植中的应用比较  

Comparison of the Application of Letrozole Combined with Menotrophins Ovulation Induction Regimen Versus Artificial Cycle Regimen in Freeze-Thaw Single Blastocyst Transplantation in Infertile Patients with Polycystic Ovary Syndrome

作　　者：翟一阳[1] 钮红丽[1] 王颖[1] 马志宾 王莉[1] 翟俊英[1] ZHAI Yi-yang;NIU Hong-li;WANG Ying;MA Zhi-bin;WANG Li;ZHAI Jun-ying(Department of Reproductive Medicine,Nanyang First People's Hospital,Nanyang 473000,China)

机构地区：[1]南阳市第一人民医院生殖医学科,南阳473000

出　　处：《中国合理用药探索》2024年第12期50-55,共6页Chinese Journal of Rational Drug Use

摘　　要：目的:比较来曲唑联合尿促性素促排卵方案与人工周期方案在多囊卵巢综合征(PCOS)不孕患者行冻融单囊胚移植中的应用效果。方法:选取2021年3月~2024年2月期间某院收治的410例PCOS不孕患者作为研究对象,根据内膜准备方案分为对照组和观察组,每组205例。对照组患者给予人工周期方案,观察组患者给予来曲唑片联合注射用尿促性素促排卵方案。比较两组患者冻融胚胎情况(胚胎冻存时间、冷冻胚胎复苏率)、子宫内膜情况(子宫内膜增殖时间、内膜转化日子宫内膜厚度、A型子宫内膜率)、胚胎移植情况(移植周期数、周期取消率、优质囊胚率)、移植日实验室指标[雌二醇(E2)、孕酮(P)]、妊娠结局(孕早期P水平、孕早期先兆流产率、孕早期自然流产率、临床妊娠率、囊胚种植率)及就诊、分娩情况(平均就诊次数、治疗总费用、早产率、活产率、妊娠时间、新生儿体重)。结果:两组患者胚胎冻存时间、冷冻胚胎复苏率、内膜转化日子宫内膜厚度、A型子宫内膜率、移植周期数、周期取消率、优质囊胚率、P水平、孕早期P水平、临床妊娠率、囊胚种植率和孕早期自然流产率、早产率、活产率、妊娠时间、新生儿体重比较均无统计学差异(P>0.05)。观察组患者子宫内膜增殖时间、孕早期先兆流产率、治疗总费用均低于对照组,E2水平、就诊次数均高于对照组(P<0.05)。结论:相比人工周期方案,来曲唑联合尿促性素促排卵方案在PCOS不孕患者行冻融单囊胚移植中的应用价值更高,可缩短患者子宫内膜增殖时间,升高E2水平,降低治疗总费用。Objective:To compare the efficacy of letrozole combined with menotrophins ovulation induction regimen versus artificial cycle regimen in freeze-thaw single blastocyst transplantation in infertile patients with polycystic ovary syndrome(PCOS).Methods:A total of 410 PCOS infertile patients admitted to a hospital from March 2021 to February 2024 were selected and divided into a control group and an observation group according to the endometrial preparation scheme,with 205 patients in each group.The control group was given artificial cycle regimen,while the observation group was given ovulation induction regimen of letrozole tablets combined with menotrophins for injection.Comparison of frozen-thawed embryos conditions(embryo freezing time,frozen embryo resuscitation rate),endometrial conditions(endometrial proliferation time,endometrial thickness on the day of endometrial transformation,type A endometrial rate),embryo transfer metrics(number of transplant cycles,cycle cancellation rate,high-quality blastocyst rate),laboratory indices on the day of transfer[estradiol(E2),progesterone(P)],pregnancy outcomes(early pregnancy P level,early pregnancy preeclampsia rate,early pregnancy spontaneous abortion rate,clinical pregnancy rate,blastocyst implantation rate)and metrics related to visits and deliveries(average number of visits,overall treatment costs,preterm birth rate,live birth rate,gestational duration,neonatal weight)were compared.Results:No statistically significant differences were observed in embryo freezing time,frozen embryo resuscitation rate,endometrial thickness on the day of endometrial transformation,type A endometrial rate,number of transplant cycles,cycle cancellation rate,high-quality blastocyst rate,P level,early pregnancy P level,clinical pregnancy rates,blastocyst implantation rate,early pregnancy spontaneous abortion rate,preterm birth rate,live birth rate,gestational duration and neonatal weight between the two groups(P>0.05).The endometrial proliferation time,early pregnancy preeclampsia rate and

关 键 词：来曲唑联合尿促性素促排卵方案 人工周期方案 多囊卵巢综合征 冻融单囊胚移植 子宫内膜 

分 类 号：R711.75[医药卫生—妇产科学]