不同热程EB病毒感染所致传染性单核细胞增多症患儿的临床表现分析  

Analysis of clinical manifestations of infectious mononucleosis in different heat duration of children with Epstein-Barr virus infection

作　　者：姚刘艳 YAO Liuyan(Department of Pediatrics,Xuzhou Maternity and Child Health Care Hospital,Jiangsu Province,Xuzhou 221009,China)

机构地区：[1]徐州市妇幼保健院儿科,江苏徐州221009

出　　处：《妇儿健康导刊》2024年第24期72-76,共5页JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE

摘　　要：目的分析不同热程EB病毒(EBV)感染所致传染性单核细胞增多症(IM)患儿的临床表现。方法回顾性分析徐州市妇幼保健院2021年8月2024年8月收治的90例EBV感染所致IM且伴发热症状的患儿,依据热程不同分为热程>7d组(22例)与热程≤7d组(68例),分析两组入院时的临床表现,比较两组实验室指标;采用logistic回归模型分析患儿热程延长的影响因素。结果热程>7d组与热程≤7d组相比,热峰、肝肿大发生率与单核细胞比例、抑制T细胞(Ts)比例、丙氨酸氨基转移酶、乳酸脱氢酶、免疫球蛋白G水平均更高(P<0.05),而辅助T细胞(Th)/Ts、Th比例均更低(P<0.05)。多因素logistic回归分析显示,肝肿大、Th/Ts是IM患儿热程延长的危险因素(P<0.05)。结论EBV感染所致IM患儿的热程不同,临床表现也存在差异。热程较长的患儿热峰更高,更易出现肝肿大,免疫系统功能更易受到损害;肝肿大、Th/Ts低是EBV感染所致IM患儿热程延长的危险因素。Objective To analyze the clinical manifestations of infectious mononucleosis(IM)in different heat duration of children with Epstein-Barr virus(EBV)infection.Methods A retrospective analysis was conducted on 90 children with IM caused by EBV accompanied by fever admitted to Xuzhou Maternity and Child Health Care Hospital from August 2021 to August 2024.According to different heat duration,the children were divided into heat duration>7 days group(22 cases)and heat duration≤7 days group(68 cases).The clinical manifestations of the two groups at admission were analyzed,the laboratory indexes of the two groups were compared,and logistic regression model was used to analyze the influencing factors of prolonged heat duration in children.Results Compared with heat duration≤7 days group,the heat peak,the incidence of hepatomegas,the proportion of monocytes,the proportion of suppressor T cell(Ts),the levels of alanine aminotransferase,lactate dehydrogenase and immunoglobulin G in heat duration>7 days group were higher(P<0.05),but the ratio of helper T cell(Th)/Ts and the proportion of Th were lower(P<0.05).Multivariate logistic regression analysis showed that liver enlargement and Th/Ts were risk factors for prolonged heat course in children with IM(P<0.05).Conclusion The clinical manifestations of IM children caused by EBV infec tion is different and the heat duration is also different.Children with longer heat duration have higher heat peak,more prone to hepatomegaly,and more prone to damage of immune system func tion.Hepatomegaly and low Th/Ts are risk factors for prolonged heat duration in children with IM caused by EBV.

关 键 词：EB病毒 传染性单核细胞增多症 热程 临床表现 

分 类 号：R725.1[医药卫生—儿科]