盐酸多西环素片、超分子水杨酸联合强脉冲光对玫瑰痤疮患者的临床疗效  

Clinical efficacy of doxycycline hydrochloride tablets,supramolecular salicylic acid combined with dual wavelength intense pulsed light in patients with rosacea

作　　者：崔俊杰[1] 尹捷 CUI Junjie;YIN Jie(Department of Cosmetic Dermatology,the Second Hospital of Traditional Chinese Medicine in Tai'an,Shandong Province,271000,China)

机构地区：[1]泰安市中医二院美容皮肤科,山东泰安271000

出　　处：《中国医疗美容》2024年第12期4-7,共4页China Medical Cosmetology

摘　　要：目的探究盐酸多西环素片、超分子水杨酸联合强脉冲光对玫瑰痤疮患者的临床疗效。方法回顾性分析2023年3月至2024年3月泰安市中医二院收治的86例玫瑰痤疮患者临床资料。根据治疗方法将其分为对照组和联合组,各43例。对照组予以口服盐酸多西环素片、面部涂抹水杨酸治疗,联合组在其基础上使用强脉冲光治疗。观察两组患者治疗效果、皮损症状改善情况、治疗前后皮肤屏障功能及生活质量,并记录两组患者在治疗期间不良反应发生状况。结果治疗后,联合组治疗总有效率高于对照组(P<0.05)。联合组生活质量、皮损症状评分低于对照组(P<0.05);皮肤屏障功能高于对照组(P<0.05);两组患者不良反应发生率比较无统计差异(P>0.05)。结论口服盐酸多西环素片、超分子水杨酸联合强脉冲光能够有效改善玫瑰痤疮患者皮损症状,安全性好、疗效显著。Objective Explore the clinical efficacy of oral doxycycline hydrochloride tablets,supramolecular salicylic acid combined with intense pulsed light in patients with rosacea.Methods The clinical data of 86 patients with rosacea admitted to the Second Hospital of Traditional Chinese Medicine in Tai'an City from March 2023 to March 2024 were retrospectively analyzed.According to the treatment methods,they were divided into a control group and a combined group,with 43 cases in each group.The control group was treated with oral doxycycline hydrochloride tablets and topical application of salicylic acid on the face,while the combined group was additionally treated with intense pulsed light on this basis.The treatment effects,improvement of skin lesion symptoms,skin barrier function and quality of life before and after treatment of the two groups of patients were observed,and the occurrence of adverse reactions during the treatment period of the two groups of patients was recorded.Results After treatment,the total effective rate of the combined group was higher than that of the control group(P<0.05).The quality of life and skin lesion symptom scores of the combined group were lower than those of the control group(P<0.05);the skin barrier function of the combined group was higher than that of the control group(P<0.05);there was no statistical difference in the incidence of adverse reactions between the two groups of patients(P>0.05).Conclusions Oral administration of doxycycline hydrochloride tablets and supramolecular salicylic acid combined with strong pulsed light can effectively improve the skin lesion symptoms of patients with rosacea,with good safety and significant efficacy.

关 键 词：盐酸多西环素片 超分子水杨酸 强脉冲光 玫瑰痤疮 

分 类 号：R75[医药卫生—皮肤病学与性病学]