血清FSTL1、GRP78对老年COPD患者疾病严重程度及再入院的评估价值  

Evaluation value of serum FSTL1 and GRP78 on disease severity and readmission in elderly COPD patients

作　　者：李亚男 夏君燕[1] 连雪梅 高永红[1] LI Yanan;XIA Junyan;LIAN Xuemei;GAO Yonghong(Department of Special Medical Treatment(Geriatrics),Beijing Aerospace General Hospital,Beijing 100076,China)

机构地区：[1]北京航天总医院干部医疗(老年医学)科,北京100076

出　　处：《国际检验医学杂志》2025年第1期44-48,共5页International Journal of Laboratory Medicine

基　　金：北京市丰台区卫生健康系统科研项目(2020-83)。

摘　　要：目的探讨血清卵泡抑素样蛋白1(FSTL1)、葡萄糖调节蛋白78(GRP78)对老年慢性阻塞性肺疾病(COPD)患者疾病严重程度及再入院的评估价值。方法选取该院于2020年3月至2023年5月收治的100例老年COPD患者作为COPD组,根据病情严重程度分为Ⅰ级(35例)、Ⅱ级(46例)、Ⅲ级(19例)。另选取同期体检的100例老年志愿者作为对照组。采用酶联免疫吸附试验(ELISA)检测两组血清FSTL1、GRP78水平。采用Spearman和Pearson相关性分析血清FSTL1、GRP78水平与一般资料的相关性,采用受试者工作特征(ROC)曲线分析COPD患者血清FSTL1、GRP78水平对疾病严重程度及再入院的评估价值。结果与对照组相比,COPD组血清FSTL1、GRP78水平均显著升高(P<0.05)。COPD患者血清FSTL1、GRP78水平随着病情严重程度增加而依次升高(P<0.05)。与非再入院组相比,再入院组患者血清FSTL1、GRP78水平显著升高(P<0.05)。Spearman相关性分析显示,血清FSTL1、GRP78水平与吸烟史、高血压史、病情严重程度呈正相关(P<0.05);Pearson相关性分析显示,血清FSTL1、GRP78水平与动脉血氧分压(PaO 2)、第1秒用力呼吸容积与用力肺活量的比值(FEV 1/FVC)、第1秒用力呼气容积占预计值百分比(FEV 1%pred)呈负相关(P<0.05),与二氧化碳分压(PaCO 2)呈正相关(P<0.05)。ROC曲线分析显示,COPD患者血清FSTL1、GRP78及二者联合评估病情严重程度及再入院的曲线下面积(AUC)均较高,并且二者联合明显均优于单独评估(P<0.05)。结论COPD患者血清FSTL1、GRP78水平均明显升高,二者与病情严重程度相关,对病情严重程度及再入院的评估价值较高。Objective To explore the evaluation value of serum follistatin like protein 1(FSTL1)and glucose regulatory protein 78(GRP78)on disease severity and readmission in elderly patients with chronic obstructive pulmonary disease(COPD).Methods A total of 100 elderly COPD patients(COPD group)treated in this hospital from March 2020 to May 2023 were selected as COPD group,and were divided into gradeⅠ(35 cases),gradeⅡ(46 cases)and gradeⅢ(19 cases)according to the severity of the disease.Another 100 elderly volunteers who underwent physical examination during the same period were selected as the control group.Serum FSTL1 and GRP78 levels were detected by enzyme-linked immunosorbent assay(ELISA).Spearman and Pearson correlation were used to analyze the correlation between serum FSTL1 and GRP78 levels and general data.The evaluation value of serum FSTL1 and GRP78 levels in COPD patients on disease severity and readmission was analyzed by receiver operating characteristics(ROC)curve.Results Compared with the control group,serum levels of FSTL1 and GRP78 in COPD group were significantly increased(P<0.05).Serum levels of FSTL1 and GRP78 in COPD patients increased with the severity of the disease(P<0.05).Compared with non-readmission group,the serum levels of FSTL1 and GRP78 in readmission group were significantly increased(P<0.05).Spearman correlation analysis showed that serum FSTL1 and GRP78 levels were positively correlated with smoking history,hypertension history and disease severity(P<0.05).Pearson correlation analysis showed that serum FSTL1 and GRP78 levels were negatively correlated with arterial oxygen pressure(PaO 2),the ratio of forced expiratory volume in the first second to forced vital capacity(FEV 1/FVC),and the percentage of forced expiratory volume in the first second to expected value(FEV 1%pred),with significance(P<0.05),while it was positively correlated with the partial pressure of carbon dioxide(PaCO 2),with significance(P<0.05).ROC curve analysis showed that serum FSTL1,GRP78 and their combined asse

关 键 词：老年慢性阻塞性肺疾病 卵泡抑素样蛋白1 葡萄糖调节蛋白78 再入院 

分 类 号：R563.9[医药卫生—呼吸系统] R446.1[医药卫生—内科学]