磺基转移酶SULTs调节糖脂代谢的研究进展  

Research progress of sulfotransferases SULTs in regulating glucose and lipid metabolism

作　　者：任亚丽(综述) 陈小朋(综述) 张校(综述) 张松(审校) REN Yali;CHEN Xiaopeng;ZHANG Xiao;ZHANG Song(School of Medicine,Wuhan University of Science and Technology,Wuhan,Hubei 430065,China;Department of Gastroenterology,General Hospital of Central Theater Comman,Wuhan,Hubei 430070,China)

机构地区：[1]武汉科技大学医学部医学院,湖北武汉430065 [2]中部战区总医院消化内科,湖北武汉430070

出　　处：《国际检验医学杂志》2025年第1期102-106,112,共6页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(82200708);湖北省自然科学基金项目(2021CFB001)。

摘　　要：人体的生物转化作用通过将外来化合物及内生物质代谢转化为极性或水溶性增加的物质,改变其毒性或药理作用并利于排出体外,在维护机体内环境稳态具有重要意义。硫酸结合反应是生物转化第二相反应的一种重要类型,主要由细胞质磺基转移酶(也称硫酸转移酶,SULTs)超家族成员介导。近年来研究发现,SULTs在药物代谢、肿瘤发生、炎症反应、激素调节、能量代谢等方面发挥重要作用。该文就SULTs超家族成员在糖脂代谢中的调控作用及分子机制进行综述,以期为糖脂代谢紊乱相关疾病的机制研究和药物研发提供新的思路。The biotransformation processes in the human body play a crucial role in maintaining the internal environment′s stability by converting exogenous compounds and endogenous metabolites into substances with increased polarity or water solubility.This alteration in toxicity or pharmacological effects facilitates their excretion from the body.Sulfation,an important type of phaseⅡbiotransformation reaction,is primarily mediated by members of the cytosolic sulfotransferases(also known as sulfotransferases,SULTs)superfamily.Recent studies have uncovered the significant roles of SULTs in drug metabolism,tumorigenesis,inflammatory responses,hormone regulation,and energy metabolism.This article provides a comprehensive review of the regulatory roles and molecular mechanisms of the SULTs superfamily members in carbohydrate and lipid metabolism,aiming to offer new insights into the mechanism research and drug development for disorders related to carbohydrate and lipid metabolism dysregulation.

关 键 词：磺基转移酶 硫酸结合反应 糖代谢 脂代谢 代谢性疾病 

分 类 号：R589.2[医药卫生—内分泌]