细菌溶解产物治疗儿童变应性鼻炎效果及对血清IFN-γ、IL-4水平的调节作用  

Effect of bacterial lysates on treatment of childhood allergic rhinitis and the regulating effect of the bacterial lysates on serum IFN-γand IL-4 levels

作　　者：谢天宏 朱文雅 王世飞 XIE Tianhong;ZHU Wenya;WANG Shifei(Department of Otolaryngology,Affiliated Hospital of Zunyi Medical University,Guizhou 563000,China)

机构地区：[1]遵义医科大学附属医院耳鼻咽喉科,贵州563000

出　　处：《中国临床新医学》2024年第12期1376-1380,共5页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：贵州省卫生健康委科学技术基金项目(编号:gzwkj2023-196)。

摘　　要：目的探讨细菌溶解产物治疗儿童变应性鼻炎的效果及对血清干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)水平的调节作用。方法招募2023年1月至2024年1月遵义医科大学附属医院耳鼻咽喉科收治的变应性鼻炎患儿60例,采用随机数字表法将其分为观察组和对照组,每组30例。对照组接受糠酸莫米松联合孟鲁司特钠治疗,观察组在对照组治疗方案基础上增加细菌溶解产物治疗,均连续治疗3个月。比较两组治疗前后血清IFN-γ、IL-4、免疫球蛋白E(IgE)、症状和体征评分,比较两组临床疗效及不良反应发生情况。结果在治疗前,两组血清IFN-γ、IL-4、IgE水平比较差异无统计学意义(P>0.05)。经治疗后,两组血清INF-γ水平均较治疗前显著升高(P<0.05),血清IL-4、IgE水平均较治疗前显著降低(P<0.05),且观察组水平变化较对照组更加显著(P<0.05)。在治疗前,两组流涕、鼻塞、鼻痒、喷嚏、鼻黏膜肿胀、下鼻甲水肿等症状和体征评分比较差异无统计学意义(P>0.05)。经治疗后,两组各症状和体征评分均较治疗前降低,且观察组评分较对照组更低,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(96.67%vs 73.33%;χ^(2)=4.706,P=0.030),两组不良反应发生率比较差异无统计学意义(20.00%vs 23.33%;χ^(2)=0.098,P=0.754)。结论细菌溶解产物有助于提升儿童变应性鼻炎的临床治疗效果,提高患儿血清INF-γ水平,降低血清IL-4、IgE水平,改善临床症状,且具有较好的安全性。Objective To explore the effect of bacterial lysates on treatment of childhood allergic rhinitis and the regulating effect of the bacterial lysates on serum interferon-γ(IFN-γ)and interleukin-4(IL-4)levels.Methods Sixty pediatric patients with allergic rhinitis who were admitted to Department of Otolaryngology,Affiliated Hospital of Zunyi Medical University from January 2023 to January 2024 were recruited and divided into observation group and control group by using random number table method,with 30 cases in each group.The control group was treated with mometasone furoate combined with montelukast sodium,and the observation group was treated with bacterial lysates on the basis of the treatment regimen of the control group.Both groups were treated continuously for 3 months.Serum IFN-γ,IL-4 and immunoglobulin E(IgE)levels,and symptom and sign scores were compared between the two groups before and after treatment,and clinical efficacy and adverse reactions were compared between the two groups.Results Before treatment,there were no significant differences in serum IFN-γ,IL-4 and IgE levels between the two groups(P>0.05).After treatment,serum INF-γlevels in both groups were significantly increased compared with those before treatment(P<0.05),while serum IL-4 and IgE levels in both groups were significantly decreased compared with those before treatment(P<0.05),and the level changes in the observation group were more significant than those in the control group(P<0.05).Before treatment,there were no significant differences in the symptom scores of runny nose,nasal congestion,nasal itching and sneezing,and the sign scores of nasal mucosal swelling and inferior turbinate edema between the two groups(P>0.05).After treatment,the scores of various symptoms and signs in both groups decreased compared with those before treatment,and the scores in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The total effective rate of the observation group was

关 键 词：细菌溶解产物 儿童变应性鼻炎 干扰素-Γ 白细胞介素-4 临床疗效 

分 类 号：R725.6[医药卫生—儿科]