生物标志物在IgA肾病诊断与预后分析中的价值  

The value of biomarkers in the diagnosis and prognostic analysis of IgA nephropathy

作　　者：卢敏 李贵森 Lu Min;Li Gui-sen(School of Medicine,University of Electronic Science and Technology of China,Department of Nephrol-ogy,Sichuan Provincial People's Hospital,Chengdu 610072,China)

机构地区：[1]电子科技大学医学院,四川省人民医院肾内科,成都610072

出　　处：《临床肾脏病杂志》2025年第1期74-78,共5页Journal Of Clinical Nephrology

摘　　要：IgA肾病(IgA nephropathy,IgAN)是世界范围内常见的原发性肾小球肾炎,也是导致慢性肾脏病和肾功能衰竭的主要原因。其病因与发病机制至今不明,目前临床上诊断该病最可靠的方法仍然是肾活检。由于存在侵入性损伤风险,肾活检通常未作为监测临床病程或预后反应的一种手段,因此亟须寻找准确可靠的无创性生物标志物为IgAN诊断和预后提供帮助。本文就近年来关于IgAN新发现的生物标志物进行分类并将研究现状进行综述,包括最新的组学技术在IgAN诊断和预后判断中的应用。Immunoglobulin A nephropathy(IgAN)is the most common primary glomerulone-phritis worldwide and the main cause of chronic kidney disease and renal failure worldwide.Its etiology and pathogenesis are still unknown,and the most reliable method for clinical diagnosis of this disease is kidney biopsy.Due to the invasive risk,renal biopsy is not usually used to monitor the clinical course or prognostic response.Therefore,it is urgent to find accurate and reliable non-invasive biomarkers for the diagnosis and prognosis of IgA nephropathy.In this paper,we reviewed the classification and current re-search status of newly discovered biomarkers in IgA nephropathy in recent years,including the applica-tion of the latest omics techniques in the diagnosis and prognosis of IgAN.

关 键 词：IGA肾病 生物标志物 诊断 预后 

分 类 号：R692.31[医药卫生—泌尿科学]