复方丹参片联合脾切除治疗重型αβ地中海贫血1例  

A case of Compound Danshen Tablets combined with splenectomy in the treatment of severe αβ thalassemia

作　　者：林忠生 黄国林 潘振南 莫丹丽 陈相武 LIN Zhongsheng;HUANG Guolin;PAN Zhennan;MO Danli;CHEN Xiangwu(Department of Surgery,Cenxi Traditional Chinese Medicine Hospital,Cenxi City,Guangxi Zhuang Autonomous Region,543200,China;Department of paediatrics,Cenxi Traditional Chinese Medicine Hospital,Cenxi City,Guangxi Zhuang Autonomous Region,543200,China;Department of Laboratory Medicine,Cenxi Traditional Chinese Medicine Hospital,Cenxi City,Guangxi Zhuang Autonomous Region,543200,China)

机构地区：[1]广西壮族自治区岑溪市中医医院外科,广西岑溪543200 [2]广西壮族自治区岑溪市中医医院儿科,广西岑溪543200 [3]广西壮族自治区岑溪市中医医院检验科,广西岑溪543200

出　　处：《蛇志》2024年第4期501-503,共3页Journal of Snake

基　　金：广西壮族自治区中医药局中医药自筹经费科研课题项目(项目名称:中药丹参施治αβ复合型地中海贫血脾切除术后观察,项目编号:GZZC2019271)。

摘　　要：报道1例重型αβ-地中海贫血(地贫):α-地贫1基因杂合子(--^(SEA)/αα)复合β-基因突变TATAboxnt-28(HBB:c,-78A→G)/β-基因突变CD 41~42(HBB:c,124~127 delTTCT)地贫双重杂合子患者。患者自幼贫血,随着年龄增长,症状逐年加重,需要输血维持,16岁时贫血明显加重,巨脾症,脾功能亢进,住院进行完整性脾切除治疗。术后,给予复方丹参片以及叶酸、维生素B_(12)、维生素E治疗,观察分析患者的临床征象、血液学指标中的红细胞、血红蛋白和免疫球蛋白。A case of severe alph aβ thalassemia:heterozygote(--^(SEA)/αα)complexβgene mutation TATAboxnt-28(HBB:c,-78A→G)/β-gene mutation CD41-42(HBB:c,124-127 delTTCT)thalassemia double heterozygote patients.Anemia since childhood,with the growth of age,the symptoms of aggravated year by year,the need for blood transfusion maintenance,anemia at 16 years old significantly aggravated,giant spleen disease,hypersplenism,hospitalization for complete splenectomy treatment.After operation,the patients were treated with Compound Danshen Tablets and Folic acid,Vitamin B_(12) and Vitamin E.The clinical signs and hematological indicators of red blood cells,hemoglobin and immunoglobulin were observed and analyzed.

关 键 词：重型αβ地中海贫血 脾切除 复方丹参片 

分 类 号：R556.61[医药卫生—血液循环系统疾病]