运动通过调节心磷脂合成及重塑干预衰老相关疾病  

Exercise mitigates aging⁃related diseases by modulating cardiolipin synthesis and remodeling

作　　者：张宸恺 王壮志 李方晖 ZHANG Chenkai;WANG Zhuangzhi;LI Fanghui(School of Sport Sciences,Nanjing Normal University,Nanjing 210000;School of Physical Education,Shihezi University,Shihezi 832003,China)

机构地区：[1]南京师范大学体育科学学院,江苏南京210000 [2]石河子大学体育学院,新疆石河子832003

出　　处：《南京医科大学学报(自然科学版)》2025年第1期71-81,共11页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金(32371180,31971099)。

摘　　要：心磷脂是维持线粒体功能所必需的脂质,通过不断重塑适应生理或病理条件下的能量需求变化。心磷脂组分的变化不仅反映了线粒体功能状态,还与多种疾病密切相关,如心肌病、帕金森病及与衰老相关的肌少症。值得注意的是,运动可通过调节多种组织的心磷脂组成与含量,帮助抵御慢性疾病对健康的侵袭。文章总结了运动和疾病状态下心磷脂动态重塑的最新研究,阐明了线粒体生物发生与心磷脂生物合成在调节线粒体功能和适应能量代谢变化中的协同作用。Cardiolipin,a pivotal lipid crucial for sustaining mitochondrial function,undergoes dynamic remodeling to accommodate fluctuating energy demands across both physiological and pathological contexts.Alterations in cardiolipin composition not only serve as indicators of mitochondrial functional states but also are intricately linked to the pathogenesis of numerous diseases,including cardiomyopathy,Parkinson’s disease,and age⁃related sarcopenia.Notably,exercise plays a crucial role in mitigating the detrimental health impacts of chronic diseases by modulating both the composition and levels of cardiolipin across various tissues.In this review,we provide a comprehensive synthesis of the latest advancements in understanding cardiolipin dynamics during exercise and pathological conditions,highlighting the synergistic interplay between mitochondrial biogenesis and cardiolipin biosynthesis in orchestrating mitochondrial function and accommodating shifts in energy metabolism.

关 键 词：心磷脂 衰老 线粒体功能 运动 

分 类 号：R592[医药卫生—老年医学]