Larvicidal and antibiofilm potential of three mountain plants:Centaurea ensiformis,Origanum hypericifolium,Paeonia turcica  

作　　者：Fatma Bursali Rukiye Yavaser Boncooğlu Mustapha Touray Mehmet Aytar Ali Celik 

机构地区：[1]Department of Biology,Faculty of Science,Aydın Adnan Menderes University,Aydın 09100,Türkiye [2]Department of Chemistry,Faculty of Science,Aydın Adnan Menderes University,Aydın 09100,Türkiye [3]Biology Department,Graduate School of Natural and Applied Sciences,Aydın Adnan Menderes University,Aydın 09100,Türkiye [4]Department of Biology,Faculty of Science,Pamukkale University,Denizli 20070,Türkiye

出　　处：《Traditional Medicine Research》2025年第4期1-10,共10页TMR传统医学研究

摘　　要：Background:Plants are known to produce a diverse group of natural metabolites with different biological activities.Centaurea ensiformis P.H.Davis,Origanum hypericifolium O.Schwartz&P.H.Davis,and Paeonia turcica Davis&Cullen are endemic plant species that grow on mountains in select regions in Türkiye and have been used in traditional Turkish medicine for various ailments.Methods:As first,we evaluated the larvicidal and antibiofilm activities of ethanol,ethyl acetate,acetone,and water extracts obtained from these plants.Antioxidant activities of the extracts were also investigated.Results:All tested extracts were effective at concentrations>25 ppm on Aedes aegypti larval mortality with the lethal concentration 50(LC_(50))values ranging between 32.82-48.35 ppm and LC90 between 46.26-63.2 ppm.O.hypericifolium was the most effective plant,ethanol extracts presented LC50 values of 32.82 ppm.Extracts demonstrated varying degrees of antibiofilm activity depending on the dose and bacterial species.Origanum hypericifolium extracts notably inhibited biofilms of Staphylococcus aureus(up to 98%inhibition),while P.turcica showed moderate efficacy against the same bacterial species.Pseudomonas aeruginosa biofilms displayed high resistance to all extracts.Conclusion:The results indicated that these endemic Turkish plants possess promising larvicidal and antibiofilm potential,particularly Origanum hypericifolium.Extracts analyzed by liquid chromatography-tandem mass spectrometry contained caffeic acid,myricetin,cinnamic acid,quercetin,gallic acid,epicatechin,and ascorbic acid.Further research should explore their potential applications in mosquito control and biofilm-related infections.

关 键 词：ANTIOXIDANT ANTIBIOFILM LARVICIDAL Centaurea ensiformis Origanum hypericifolium Paeonia turcica LC-MS/MS 

分 类 号：R96[医药卫生—药理学]