Evaluating FFA and UWF SS-OCTA abnormalities in X-linked retinoschisis:a cross-sectional study of 46 eyes  

作　　者：Linyan Zhang Xiongze Zhang Miner Yuan Limei Sun Xianghua Wu Shuya Ke Xiaoyan Ding 张林燕;张雄泽;袁敏而;孙立梅;吴向华;柯淑雅;丁小燕(State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,China)

机构地区：[1]State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science,Guangzhou 510060,China

出　　处：《Eye Science》2024年第4期381-392,共12页眼科学报(英文版)

基　　金：supported by the Construction Project of High-Level Hospitals in Guangdong Province(303020107,303010303058);the National Natural Science Foundation of China(82271092,82401282);Guangdong Basic and Applied Research Foundation(2023A1515010430);Guangzhou Municipal Science and Technology Key Project(2024A03J0171).

摘　　要：Aims:This study describes vascular abnormalities in X-linked retinoschisis(XLRS)using fundus fluorescein angiography(FFA)and ultra-widefield swept-source optical coherence tomography angiography(UWF SS-OCTA)to better understand the disease's vascular features and impact.Methods:A retrospective cross-sectional study was conducted on 26 XLRS patients(46 eyes).A comprehensive ophthalmic examination was performed,including FFA and UWF SS-OCTA.FFA abnormalities were divided into peripheral schisis-associated and optic disc-associated types.Results:The mean age of patients was 11.3±6.5 years.Macular schisis appeared in 97.8%of eyes,peripheral schisis in 89.1%,and peripheral bullous schisis(PBS)in 67.39%.Major vascular changes identified by FFA included dendritic capillary dilation/leakage(91.3%),internal residual vessel leakage(78.3%),and capillary dropout/ischemia(71.7%).Minor changes included zonal retinal pigment epithelium(RPE)proliferation(6.5%),bridging vessels(4.4%),and capillary sheathing(4.4%).peripapillary choroidal neovascularization(PPCNV)was noted in 10.9%and situs inversus of optic disc in 13.0%of eyes.Additionally,situs in versus of optic disc and zonal RPE proliferation were novel findings.Major FFA changes correlated with broader PBS(P=0.045)(P<0.001)(P=0.003).Clock hours of PBS were significant predictors for internal residual vessel leakage(OR=0.30,P=0.03).No significant correlation was found between gene mutation type and FFA abnormalities(P=0.539).Conclusions:This study highlighted the significant prevalence(95.7%)of vascular abnormalities in XLRS and emphasized the importance of combining FFA with UWF SS-OCTA for comprehensive evaluation,enhancing the understanding of XLRS pathophysiology and aiding in targeted treatment approaches.

关 键 词：X-linked retinoschisis retinal vascular changes FFA ultrawide field swept source OCT peripheral schisis 

分 类 号：R58[医药卫生—内分泌]