Considerations regarding the application of Chinese herbal medicine-derived extracellular vesicle-like particles in a drug delivery system  

作　　者：Fucai Chen Yingjie Zhang Yu Zheng Longxiang Pan Jiale Li Liuqing Di Peng Cao Ruoning Wang 

机构地区：[1]School of Pharmacy,Nanjing University of Chinese Medicine,Nanjing,China [2]Jiangsu Provincial TCM Engineering Technology Research Center of High Efficient Drug Delivery System,Nanjing,China [3]Jiangsu Provincial Medical Innovation Center,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Nanjing,China

出　　处：《Acupuncture and Herbal Medicine》2024年第4期423-426,共4页针灸和草药(英文)

基　　金：supported by National Natural Science Foundation of China(82125037,82274104,82074024,82374042);Jiangsu Provincial Medical Innovation Center(CXZX202225);Natural Science Foundation Youth Project of Nanjing University of Chinese Medicine(NZY81903557);the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine(2020YLXK019);Young Elite Scientists Sponsorship Program by CACM(2021-QNRC2-A01).

摘　　要：“Chinese herbal medicine extracellular vesicles-like particles”(CHM-EVLPs)refer to vesicle-like nanoparticles secreted by Chinese herbal medicines.These particles possess a lipid bilayer framework and contain various proteins,nucleic acids,and other active substances.Accumulating evidence suggests that CHM-EVLPs play crucial roles in regulating communication between mammals and plants,tissue repair,self-defense,and disease treatment.Their unique vesicle-like structure and excellent biocompatibility make them ideal drug delivery carriers for DNA and small molecule drugs.In recent years,studies focusing on utilizing CHM-EVLPs as delivery carriers have emerged as a prominent field in advancing the modernization of traditional Chinese medicine.However,several issues pertaining to security,standards in definition,methods of extraction and separation,and clinical application persist.The future research of CHMEVLPs in disease treatment and drug delivery,along with potential challenges,is discussed in the following four sections.

关 键 词：HERBAL application utilizing 

分 类 号：R28[医药卫生—中药学]