利福喷丁与利福平在肺结核治疗中的疗效及其对肝功能影响研究  

Study on the Efficacy and Liver Function Impact of Rifapentine and Rifampicin in the Treatment of Pulmonary Tuberculosis

作　　者：李岐 孙晟 LI Qi;SUN Sheng(Tongshan County People's Hospital,Tongshan Hubei 437699,China)

机构地区：[1]通山县人民医院,湖北通山437699 [2]泰康同济(武汉)医院药学部

出　　处：《湖北科技学院学报(医学版)》2025年第1期43-47,共5页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的分析利福喷丁与利福平在肺结核治疗中的疗效及其对肝功能影响。方法选取本院收治的82例肺结核患者为研究对象,均使用抗结核治疗方案,将采用利福平片治疗的41例患者纳入对照组,将采用利福喷丁治疗的41例患者纳入观察组,观察两组痰涂片转阴率、空洞闭合率、病灶吸收率、临床治疗效果、肝功能情况、T细胞亚群水平、鸟苷酸结合蛋白5(GBP5)表达量及药物不良反应。结果用药后6个月,观察组涂片转阴率、空洞闭合率、病灶吸收率、治疗有效率较对照组高(P均<0.05);两组肝功能各指标均较治疗前高(P<0.05),但观察组均较对照组低(P<0.05);两组CD3+、CD8^(+)指标比治疗前低,CD4^(+)、CD4^(+)/CD8^(+)指标均较治疗前高(P<0.05),GBP5均较治疗前低(P<0.05),且观察组比对照组更显著(P均<0.05);观察组不良反应较对照组少(P<0.05)。结论肺结核治疗中采用常规抗结核治疗方案的同时辅以利福喷丁治疗效果相对更好,且药物不良反应发生率低,使用价值较好。Objective To analyze the efficacy and liver function impact of rifapentine and rifampicin in the treatment of tuberculosis.Methods 82 patients with pulmonary tuberculosis who were admitted and treated in our hospitals were selected as the research subjects.All patients were received anti-tuberculosis treatment plan.41 patients were included in the control group and treated with rifampicin tablets,the other 41 patients were included in the observation group and treated with rifampicin.The sputum smear conversion rate,cavity closure rate,lesion absorption rate,clinical treatment effect,liver function,T cell subpopulation level,GBP5 expression level,and drug adverse reactions were observed in both groups.Results After 6 months of medication,the observation group had a higher rate of sputum smear conversion,cavity closure,lesion absorption and clinical treatment effect than those in the control group(P<0.05).All liver function indicators in both groups were higher than the indicators before treatment(P<0.05).But the observation group was lower than the control group(P<0.05).The CD3+and CD8^(+)indicators in both groups were lower than the value before treatment,while the CD4^(+)and CD4^(+)/CD8^(+)indicators were higher than the value before treatment(P<0.05).The GBP5 levels in both groups were lower than the levels before treatment(P<0.05),and the level in the observation group was more significant(P<0.05).The observation group had the fewer adverse reactions compared to the control group(P<0.05).Conclusion In the treatment of pulmonary tuberculosis,the use of conventional anti-tuberculosis therapy combined with rifapentine treatment is relatively more effective,as well as the lower incidence of adverse drug reactions and higher use value.

关 键 词：肺结核 利福喷丁 利福平 痰涂片转阴率 肝功能指标 T细胞亚群 

分 类 号：R521[医药卫生—内科学]