Therapeutic potential of Carum carvi in depression,memory loss,and hippocampal sclerosis reversal in temporal lobe epilepsy  

作　　者：Muhammad Wasim Syeda Arfa Mairaj Hasan Salman Siddiqi Mahwish Fatima Saara Ahmad Fazal Manzoor Arain 

机构地区：[1]Department of Biological and Biomedical Sciences,The Aga Khan University,Karachi 74800,Pakistan [2]Maternal and Children's Health Research Institute,Shunde Women and Children's Hospital,Guangdong Medical University,Foshan 528300,China

出　　处：《Traditional Medicine Research》2025年第3期1-7,共7页TMR传统医学研究

基　　金：supported by the URC Aga Khan University(Project ID:212003);Pakistan Science Foundation(Project Code:710110-201-20001-500-53413-0000).

摘　　要：Background:Epilepsy is a disease characterized by unprovoked seizures,and it affects around 70 million people worldwide.Standard treatment is ineffective in one third of all epilepsy patients.Temporal Lobe Epilepsy with Hippocampal Sclerosis(TLE-HS)is the most drug-resistant form of epilepsy,and it also impacts physical,mental,and psychological well-being of patients.Carum carvi extract has demonstrated anti-convulsant,anti-depressant,and anxiolytic properties.This study was designed to investigate if Carum carvi extract can alleviate depression and memory loss symptoms in a TLE-HS animal model.Methods:Male Sprague Dawley rats were used to create a model of TLE-HS and Carum carvi extract treatment,along with appropriate controls,was used to test the efficacy of this herbal extract in reducing the symptoms of depression and memory loss.Results:Forced swim test showed that Carum carvi extract treated TLE-HS rats resulted in significant improvement of the symptoms of depression.However,novel object recognition test showed that memory improvement did not occur.Conclusion:Depression significantly impacts the quality of life in TLE-HS patients,and this study has shown that Carum carvi extract should be explored further as an adjuvant treatment for TLE-HS patients to improve their quality of life.

关 键 词：EPILEPSY Carum carvi DEPRESSION memory loss hippocampal sclerosis 

分 类 号：R74[医药卫生—神经病学与精神病学]