脑钠肽、脂蛋白相关磷脂酶A2及低密度脂蛋白胆固醇与冠状动脉粥样硬化性心脏病的相关性分析  

Correlation analysis of brain natriuretic peptide,lipoprotein-associated phospholipase A2 and low density lipoprotein cholesterol with coronary atherosclerotic heart disease

作　　者：李艳[1] Li Yan(Department of Medical Laboratory,Zhengzhou First People's Hospital,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州市第一人民医院检验科,河南郑州450000

出　　处：《感染、炎症、修复》2024年第4期292-296,共5页Infection Inflammation Repair

摘　　要：目的:分析脑钠肽(BNP)、脂蛋白相关磷脂酶A2(LP-PLA2)、低密度脂蛋白胆固醇(LDL-C)与冠状动脉粥样硬化性心脏病(CHD)之间的关系。方法:回顾性分析郑州市第一人民医院2023年2月至2024年2月收治的68例CHD患者,根据冠脉造影结果将CHD患者分为冠状动脉单支病变32例、双支病变21例、3支病变15例;同时选取我院同期收治的65例非CHD患者的临床资料,分别纳入CHD组和非CHD组。对比CHD组和非CHD组患者的临床资料及实验室指标,分析CHD发生的影响因素,比较不同冠脉狭窄程度CHD患者BNP、Lp-PLA2及LDL-C水平变化,并分析研究指标与CHD患者冠脉狭窄程度的相关性以及对CHD的诊断价值。结果:CHD组BNP、Lp-PLA2、LDL-C水平均高于非CHD组(P<0.001);≥中位数水平的BNP(OR=3.093,95%CI:1.521-6.287)、Lp-PLA2(OR=3.684,95%CI:1.777-7.638)、LDL-C(OR=2.489,95%CI:1.351-4.588)均是导致CHD发生的独立危险因素(P<0.001);3支病变患者的BNP、Lp-PLA2、LDL-C水平均高于单支病变和双支病变患者(P<0.001),双支病变患者的BNP、Lp-PLA2、LDL-C水平均高于单支病变患者(P<0.001);BNP、Lp-PLA2、LDL-C水平与冠脉狭窄程度均呈正相关(r=0.737、0.757、0.720,P<0.001);BNP、Lp-PLA2、LDL-C水平及三者联合诊断CHD的曲线下面积(AUC)分别为0.893、0.888、0.867、0.897,诊断效能均较高(P<0.001)。结论:CHD的发生与BNP、Lp-PLA2、LDL-C水平存在密切联系,且BNP、Lp-PLA2、LDL-C水平与冠脉狭窄程度呈正相关,临床可通过检测BNP、Lp-PLA2、LDL-C水平作为CHD的预测指标。Objective:To analyze the relationship between brain natriuretic peptide(BNP),lipoprotein-associated phospholipase A2(Lp-PLA2)and low density lipoprotein cholesterol(LDL-C)and coronary atherosclerotic heart disease(CHD).Methods:Sixty-eight patients with CHD admitted to Zhengzhou First People's Hospital from February 2023 to February 2024 were retrospectively analyzed.According to the results of coronary angiography,the CHD patients were divided into 32 cases with single coronary artery disease,21 cases with double coronary artery disease and 15 cases with 3 coronary artery disease.At the same time,the clinical data of 65 patients with non-CHD admitted in the same hospital during the same period were selected and included into the CHD group and non-CHD group,respectively.The clinical data and laboratory indicators were compared between CHD group and non-CHD group.The influencing factors of CHD occurrence were analyzed,the changes in BNP,Lp-PLA2 and LDL-C levels in CHD patients with different degrees of coronary stenosis were compared,and the correlation between the study indexes and the degree of coronary stenosis in CHD and the diagnostic value of CHD were analyzed.Results:The levels of BNP,Lp-PLA2,and LDL-C in the CHD group were all higher than those in the non-CHD group(P<0.001).BNP≥median level(OR=3.093,95%CI:1.521-6.287),Lp-PLA2(OR=3.684,95%CI:1.777-7.638),and LDL-C(OR=2.489,95%CI:1.351-4.588)were independent risk factors for CHD(P<0.001).The levels of BNP,Lp-PLA2 and LDL-C in patients with three-branch lesions were higher than those in patients with single-branch and double-branch lesions(P<0.001).Also,the levels of BNP,Lp-PLA2 and LDL-C were positively correlated with the degree of coronary stenosis(r=0.737,0.757,0.720,P<0.001).The levels of BNP,Lp-PLA2 and LDL-C and the area under the curve(AUC)of the combined diagnosis of CHD were 0.893,0.888,0.867 and 0.897,respectively,showing high diagnostic efficacy(P<0.001).Conclusions:The occurrence of CHD is closely related to BNP,Lp-PLA2 and LDL-C,and the levels

关 键 词：脑钠肽 脂蛋白相关磷脂酶A2 低密度脂蛋白胆固醇 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病]