有创呼吸机治疗对重症肺炎患者动态血气和炎症等参数的影响  

Influence of invasive ventilator treatment on dynamic blood gas,inflammation and other parameters in patients with severe pneumonia

作　　者：林钧 张小华 林群 Lin Jun;Zhang Xiaohua;Lin Qun(Department of Emergency,Fuqing Hospital of Fujian,Fuqing,Fujian 350300,China)

机构地区：[1]福建省福清市医院急诊科,福建福清350300

出　　处：《感染、炎症、修复》2024年第4期297-300,共4页Infection Inflammation Repair

摘　　要：目的:探讨有创呼吸机治疗对重症肺炎(SP)患者动态血气、炎症等参数的影响。方法:80例2018年1月至2022年12月在福建省福清市医院就诊的SP患者。根据呼吸支持治疗方案的不同分为两组,每组40例。在常规对症治疗基础上对照组接受无创呼吸机治疗,观察组接受有创呼吸机治疗。比较两组血气分析指标、炎症指标和并发症发生情况。结果:治疗前两组间C反应蛋白(CRP)和降钙素原(PCT)水平及乳酸、Δ二氧化碳分压[ΔPaCO_(2)(|PaCO_(2)-40.0|)]、动脉血氧分压(PaO_(2))、氧合指数均无显著性差异(P>0.05)。治疗后两组的两个炎症指标均下降(P<0.001)。观察组治疗后第7天的CRP、PCT、乳酸水平和治疗后第3、7天的ΔPaCO_(2)均低于对照组,治疗第3、7天的PaO_(2)和氧合指数均高于对照组;且并发症发生率更低(P<0.05)。结论:SP患者应用有创呼吸机治疗,可动态化改善患者血气分析参数,减轻炎症反应,降低并发症发生率,改善预后效果,值得推荐。Objective:To explore the influence of invasive ventilator treatment on dynamic blood gas,inflammation and other parameters in patients with severe pneumonia(SP).Methods:A total of 80 patients with SP admitted to Fuqing Hospital of Fujian from January 2018 to December 2022 were retrospectively analyzed.Patients were divided into two groups according to different respiratory support treatment plans,with 40 cases in each group.On the basis of conventional symptomatic treatment,the control group received routine treatment,while the observation group received invasive ventilator treatment.Blood gas analysis indicators,inflammation indicators and incidence of complications between two groups were compared.Results:There were no significant differences in C-reactive protein(CRP)and procalcitonin(PCT)levels,lactic acid,Δpartial pressure of carbon dioxide[ΔPaCO_(2)(|PaCO_(2)-40.0|)],partial pressure of arterial oxygen(PaO_(2))and oxygenation index between two groups before treatment(P>0.05).After treatment,both inflammatory markers decreased in both groups(P<0.001).The levels of CRP,PCT,lactic acid andΔPaCO_(2) at day 7 after treatment in the observation group were lower than those in the control group,and the PaO_(2) and oxygenation index at day 3 and 7 after treatment were higher than those in the control group.The complication rate was lower(P<0.05).Conclusions:Invasive ventilator treatment applied in patients with SP can dynamically improve blood gas analysis parameters,alleviate inflammatory reactions,reduce the incidence of complications,and improve prognosis.It is worthy of recommendation.

关 键 词：肺炎 重症 有创呼吸机 血气分析 并发症 

分 类 号：R563.1[医药卫生—呼吸系统]