非高密度与高密度脂蛋白胆固醇比值与老年冠心病患者冠状动脉不稳定性斑块形成的关系  

Relationship Between Non-high Density and High Density Lipoprotein Cholesterol Ratio and Coronary Artery Unstable Plaque Formation in Elderly Cases with Coronary Heart Disease

作　　者：朱璞 刘慧 刘娜 ZHU Pu;LIU Hui;LIU Na(Department of Laboratory Medicine,Shangqiu Third People’s Hospital,Shangqiu 476000,China;Department of Laboratory Medicine,Zhongzhou Community Health Service Center,Liangyuan District,Shangqiu City,Shangqiu 476000,China)

机构地区：[1]商丘市第三人民医院检验科,河南商丘476000 [2]商丘市梁园区中州社区卫生服务中心检验科,河南商丘476000

出　　处：《河南医学研究》2025年第1期92-95,共4页Henan Medical Research

摘　　要：目的探讨非高密度与高密度脂蛋白胆固醇比值(non-HDL-C/HDL-C)与老年冠心病患者冠状动脉不稳定性斑块形成的关系。方法选取2018年12月至2022年12月商丘市第三人民医院收治的206例老年冠心病患者为研究组,另选同期200例健康体检者作为健康组。采用生化仪检测血脂水平并计算non-HDL-C/HDL-C比值。根据冠状动脉内超声显像结果将患者分为不稳定斑块组(66例)和稳定斑块组(140例)。采用受试者工作特征曲线评估non-HDL-C/HDL-C比值对冠状动脉不稳定性斑块的预测价值,采用多因素logistic回归分析探讨影响因素。结果研究组non-HDL-C和non-HDL-C/HDL比值均高于健康组,HDL-C低于健康组(P<0.05);不稳定组non-HDL-C和non-HDL-C/HDL-C比值均高于稳定组,HDL-C低于稳定组(P<0.05)。non-HDL-C、HDL-C预测冠状动脉不稳定性斑块的曲线下面积分别为0.814、0.727,non-HDL-C/HDL-C比值预测的曲线下面积为0.901。多因素logistic回归分析显示,non-HDL-C/HDL-C比值≥5.655(OR=3.501,95%CI:2.132~5.748)是老年患者冠状动脉不稳定性斑块的影响因素之一(P<0.05)。结论non-HDL-C/HDL-C比值升高与老年冠心病患者冠状动脉不稳定性斑块形成密切相关,有望作为评估老年冠心病患者冠状动脉不稳定性斑块形成的生物学指标。Objective To explore the relationship between non-high density and high density lipoprotein cholesterol ratio(non-HDL-C/HDL-C)and the coronary artery unstable plaque in elderly cases with coronary heart disease.Methods A total of 206 elderly cases with coronary heart disease treated in Shangqiu Third People’s Hospital from December 2018 to December 2022 were selected as the study group,and 200 healthy physical examination subjects who came to Shangqiu Third People’s Hospital during the same period were selected as the health group.Blood lipid levels were measured by biochemical analyzer and the non-HDL-C/HDL-C ratio was calculated.Elderly cases with coronary heart disease were divided into unstable plaque group(66 cases)and stable plaque group(140 cases)by the intracoronary ultrasound imaging.The predictive value of non-HDL-C/HDL-C ratio on coronary artery unstable plaque in elderly cases with coronary heart disease was evaluated by ROC.The influencing factors was explored by multivariate logistic regression analysis.Results The non-HDL-C and non-HDL-C/HDL ratio in study group were higher than those in healthy group,and the HDL-C was lower than that in healthy group(P<0.05).The non-HDL-C and non-HDL-C/HDL-C ratio in unstable group were higher than that in stable group,and HDL-C was lower than that in stable group(P<0.05).The area under the curve of non-HDL-C and HDL-C for predicting the coronary artery unstable plaque in elderly cases with coronary heart disease were 0.814 and 0.727,and the area under the curve predicted by the non-HDL-C/HDL-C ratio was 0.901.The non-HDL-C/HDL-C ratio≥5.655(OR=3.501,95%CI:2.132-5.748)was one of the factors affecting the coronary artery unstable plaque in elderly cases with coronary heart disease(P<0.05).Conclusion The increase of non-HDL-C/HDL-C ratio is closely related to the formation of coronary artery unstable plaque in elderly patients with coronary heart disease,and is expected to be used as a biological indicator to evaluate the formation of coronary artery unstable

关 键 词：冠心病 冠状动脉斑块 老年 非高密度脂蛋白胆固醇 高密度脂蛋白胆固醇 

分 类 号：R541.4[医药卫生—心血管疾病]