AngioJet机械性血栓抽吸治疗下肢动脉硬化闭塞症的效果及预后  

Effect and Prognosis of Angiojet Mechanical Thrombus Aspiration in the Treatment of Arteriosclerosis Obliterans of Lower Limbs

作　　者：周小巍 朱敬伟 李忠 ZHOU Xiaowei;ZHU Jingwei;LI Zhong(Interventional Department,Zhumadian Traditional Chinese Medicine Hospital,Zhumadian 463000,China)

机构地区：[1]驻马店市中医院介入科,河南驻马店463000

出　　处：《河南医学研究》2025年第1期103-107,共5页Henan Medical Research

摘　　要：目的探讨AngioJet机械性血栓抽吸治疗下肢动脉硬化闭塞症的效果及预后。方法选取2020年1月至2022年6月驻马店市中医院诊治的72例下肢动脉硬化闭塞症患者作为研究对象,按照随机数字表法分为对照组[接受导管接触性溶栓(CDT)治疗]与观察组(接受AngioJet机械性血栓抽吸联合CDT治疗),各36例。对比两组Rutherford分级、尿激酶用量、溶栓时间、住院时间、超声血流动力学[收缩期峰值血流速度(PSV)、阻力指数(RI)]、C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、细胞间黏附分子-1(ICAM-1)及术后1 a内的靶血管重建率、复发率、截肢率、病死率。结果治疗后,观察组的Rutherford分级优于对照组(P<0.05);观察组的尿激酶用量少于对照组,溶栓时间、住院时间均短于对照组(P<0.05);观察组胫后动脉、足背动脉的PSV均高于对照组,而CRP、TNF-α、IL-6、ICAM-1、RI低于对照组(P<0.05);观察组术后1 a内的靶血管重建率、复发率均低于对照组(P<0.05);两组截肢率、病死率比较,差异无统计学意义(P>0.05)。结论AngioJet机械性血栓抽吸治疗下肢动脉硬化闭塞症有利于改善下肢血流动力学,并降低靶血管重建率、复发率。Objective To explore the effectiveness and prognostic of AngioJet mechanical thrombus aspiration in the treatment of arteriosclerosis obliterans of lower limbs.Methods A total of 72 patients with arteriosclerosis obliterans of lower limbs diagnosed and treated from January 2020 to June 2022 were selected as the study subjects.They were randomly divided into control group[received catheter-directed thrombolysis(CDT)]and observation group(received AngioJet mechanical thrombus aspiration combined with CDT)using a random number table method,with 36 patients in each group.Rutherford grade,urokinase dosage,thrombolysis time,hospital stay,ultrasound hemodynamics[peak systolic velocity(PSV),resistance index(RI)],C-reactive protein(CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),intercellular adhesion molecule 1(ICAM-1)and target vessel reconstruction rate,recurrence rate,amputation rate and case fatality rate within 1 year after operation were compared between the two groups.Results After treatment,the Rutherford grading of the observation group was better than that of the control group(P<0.05).The urokinase dosage in the observation group was less than that in the control group,thrombolysis time and hospital stay in the observation group were shorter than those in the control group(P<0.05).The PSV of the posterior tibial artery and dorsal pedis artery in the observation group were higher than those in the control group,while CRP and TNF-α、IL-6,ICAM-1,RI were lower in the control group(P<0.05).The target vessel reconstruction rate and recurrence rate in the observation group within one year after surgery were lower than those in the control group(P<0.05).There was no statistically significant difference in amputation rate and case fatality rate between the two groups(P>0.05).Conclusion AngioJet mechanical thrombus aspiration therapy for arteriosclerosis obliterans of lower limbs is beneficial for improving lower limb hemodynamics and reducing target vessel reconstruction and recurrence rates.

关 键 词：下肢动脉硬化闭塞症 AngioJet机械性血栓抽吸 预后 

分 类 号：R654.4[医药卫生—外科学]