智能响应型水凝胶及其在药物控释中的应用  

Smart responsive hydrogels and their application in controlled drug release

作　　者：罗启培 张新春[1] Luo Qipei;Zhang Xinchun(Dept.of Prosthodontics,Guanghua School of Stomatology,Hospital of Stomatology,Sun Yat-sen University&Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]中山大学光华口腔医学院·附属口腔医院修复科、广东省口腔医学重点实验室,广州510055

出　　处：《国际口腔医学杂志》2025年第1期123-132,共10页International Journal of Stomatology

基　　金：广东省自然科学基金(2022A1515012485)。

摘　　要：水凝胶是一类易于功能化修饰及负载药物的聚合物材料,在药物递送领域已得到广泛的应用。智能响应型水凝胶相比传统水凝胶具有刺激响应性,避免了传统水凝胶的早期爆释药物现象,可响应病理情况下的微环境变化或响应外加刺激从而实现按需控释药物,是更为智能的药物递送系统。本文全面综述了pH、活性氧、化学、温度、磁、光、超声响应型水凝胶独特的响应机制以及在各类疾病治疗中药物控释的创新应用,展现了这一领域的前沿进展并指出了未来研究的发展方向。Hydrogels are polymeric materials with advantageous properties of facile functionalization and drug encap‐sulation,rendering them applicable in drug delivery.Compared with regular hydrogels,smart responsive hydrogels are su‐perior drug delivery systems due to their ability to intelligently respond to stimuli and avoid burst drug release in the early stage.These hydrogels can effectively react to microenvironmental alterations in disease conditions or external stimuli,hence enabling precise and timely controlled drug release.In this work,the unique response mechanism of hydrogels re‐sponsive to pH,reactive oxygen species,chemical,temperature,magnetic,light and ultrasound and their innovative appli‐cation in the treatment of various diseases are reviewed.The findings present the frontier progress in this field and point out the development direction of future research.

关 键 词：水凝胶 智能响应型水凝胶 药物递送 药物控制释放 

分 类 号：R452[医药卫生—治疗学]